Pentocin KCA1

Accession: BAC224

Default view

Bacteriocin: Pentocin KCA1

Accession: BAC224

Classification

Class: Cyclic bacteriocin (Class V)

Genetics

Gene: KCA1_0433

Producer and target organisms

Producer Organism: Lactobacillus pentosus KCA1 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Target organisms~~Unavailable data~~

Description

Pentocin A is a mature putative circular bacteriocin consisting of alpha-helical structures and has a high proportion of basic amino acid residues.

Uniprot and PDB links

UniProt Entry: I9APR2

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE, STRAIN=KCA1.
PubMed=23527145;
Anukam K.C., Macklaim J.M., Gloor G.B., Reid G., Boekhorst J., Renckens B., van Hijum S.A., Siezen R.J.
"Genome Sequence of Lactobacillus pentosus KCA1: Vaginal Isolate from a Healthy Premenopausal Woman.", PLoS ONE 8:E59239-E59239(2013).

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60
| | | | | |
IVWLANKFGV HLTNHLTNSI LNAVSNGSSL GSAFAVIAGV TLPGWAVAAV GALGATAA

Wheel representation

Composition

Amino acid	Count	Percent
A	12	20.69 %
C	0	0.00 %
D	0	0.00 %
E	0	0.00 %
F	2	3.45 %
G	7	12.07 %
H	2	3.45 %
I	3	5.17 %
K	1	1.72 %
L	7	12.07 %
M	0	0.00 %
N	5	8.62 %
P	1	1.72 %
Q	0	0.00 %
R	0	0.00 %
S	5	8.62 %
T	4	6.90 %
V	7	12.07 %
W	2	3.45 %
Y	0	0.00 %

Hydrophobicity

Composition

Formula	C₀ H₀ N₀ O₀ S₀
Absent amino acids	CDEMQRY
Common amino acids	A
Mass (Da)	5
Net charge	+3
Isoelectric point	9.7
Basic residues	3
Acidic residues	0
Hydrophobic residues	33
Polar residues	21
Aliphatic residues	17
Tiny residues	24
Boman Index	41.05
Hydropathy Index	0.964
Aliphatic Index	122.93
Instability Index	10.44 (stable)
Half Life	Mammalian : 20 hour Yeast : 30 min E. coli : >10 hour
Extinction Coefficient	11000 M^-1 cm^-1
Absorbance 280nm	192.98