Bacteriocin: Bactofencin A
Accession: BAC221
Classification
Class: Unclassified
Genetics
Gene: bfnA
Producer and target organisms
Producer Organism: Lactobacillus salivarius DPC6502 [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Target organismslactobacilli - Staphylococcus aureus - Listeria innocua
Uniprot and PDB links
UniProt Entry: V6DMD2
PDB EntryUnknown
NUCLEOTIDE SEQUENCE.
PubMed=24526652;DOI=10.1128/genomeA.01231-13
Mackenzie D.A., McLay K., Roos S., Walter J., Swarbreck D., Drou N., Crossman L.C., Juge N.
"Draft Genome Sequence of a Novel Lactobacillus salivarius Strain Isolated from Piglet.", Genome Announc. 2:e01231-e01213(2014).
PubMed=24526652;DOI=10.1128/genomeA.01231-13
Mackenzie D.A., McLay K., Roos S., Walter J., Swarbreck D., Drou N., Crossman L.C., Juge N.
"Draft Genome Sequence of a Novel Lactobacillus salivarius Strain Isolated from Piglet.", Genome Announc. 2:e01231-e01213(2014).
SEQUENCE AND ACTIVITY.
PubMed=24169573;DOI=10.1128/mBio.00498-13
O'Shea E.F., O'Connor P.M., O'Sullivan O., Cotter P.D., Ross R.P., Hill C.
"Bactofencin A, a new type of cationic bacteriocin with unusual immunity", MBio. 4(6):e00498-13 (2013).
PubMed=24169573;DOI=10.1128/mBio.00498-13
O'Shea E.F., O'Connor P.M., O'Sullivan O., Cotter P.D., Ross R.P., Hill C.
"Bactofencin A, a new type of cationic bacteriocin with unusual immunity", MBio. 4(6):e00498-13 (2013).
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Protein sequence
| ........10 ........20 ........30 | | | KRKKHRCRVY NNGMPTGMYR WC |
Wheel representation
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 0 | 0.00 % |
| C | 2 | 9.09 % |
| D | 0 | 0.00 % |
| E | 0 | 0.00 % |
| F | 0 | 0.00 % |
| G | 2 | 9.09 % |
| H | 1 | 4.55 % |
| I | 0 | 0.00 % |
| K | 3 | 13.64 % |
| L | 0 | 0.00 % |
| M | 2 | 9.09 % |
| N | 2 | 9.09 % |
| P | 1 | 4.55 % |
| Q | 0 | 0.00 % |
| R | 4 | 18.18 % |
| S | 0 | 0.00 % |
| T | 1 | 4.55 % |
| V | 1 | 4.55 % |
| W | 1 | 4.55 % |
| Y | 2 | 9.09 % |
Hydrophobicity
Composition
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | ADEFILQS |
| Common amino acids | R |
| Mass (Da) | 2782.69 |
| Net charge | +8 |
| Isoelectric point | 11.12 |
| Basic residues | 8 |
| Acidic residues | 0 |
| Hydrophobic residues | 2 |
| Polar residues | 9 |
| Aliphatic residues | 1 |
| Tiny residues | 2 |
| Boman Index | -81.61 |
| Hydropathy Index | -1.523 |
| Aliphatic Index | 13.18 |
| Instability Index | 59.33 (unstable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 8605 M-1 cm-1 |
| Absorbance 280nm | 409.76 |