Leucocyclicin Q

Accession: BAC209

Default view

Bacteriocin: Leucocyclicin Q

Accession: BAC209
Classification
Class: Unclassified
Genetics
Gene: lcyQ
Producer and target organisms

Producer Organism: Leuconostoc mesenteroides TK41401 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLeuconostoc

Target organismsUnknown error type: [8] Uninitialized string offset: -1
Lactococcus lactis ssp. lactis JCM 7638 (MIC=0.038µM) - Lactococcus lactis ssp. lactis ATCC 19435 (MIC=0.038µM) - Lactococcus sp. QU 12 (MIC=1.203µM) - Lactobacillus sakei ssp. sakei JCM 1157 (MIC=0.038µM) - Weissella cibaria JCM 12495 (MIC=2.405µM) - Weissella paramesenteroides JCM 9890 (MIC=0.075µM) - Pediococcus pentosaceus JCM 5885 (MIC=2.405µM) - Pediococcus dextrinicus JCM 5887 (MIC=0.038µM) - Enterococcus faecium JCM 5804 (MIC=0.038µM) - Enterococcus faecalis JCM 5803 (MIC=0.15µM) - Streptococcus salivarius JCM 5707 (MIC=2.405µM) - Streptococcus bovis JCM 5802 (MIC=0.601µM) - Streptococcus mutans JCM 5705 (MIC=19.25µM) - Bacillus coagulans JCM 2257 (MIC=0.075µM) - Bacillus subtilis ssp. subtilis JCM 1465 (MIC=0.601µM) - Bacillus cereus JCM 2152 (MIC=2.405µM) - Kocuria rhizophila NBRC 12708 (MIC=9.623µM) - Listeria innocua ATCC 33090 (MIC=0.601µM) - Leuconostoc mesenteroides ssp. mes. JCM 6124 (MIC=0.3µM) - Escherichia coli JM109 (MIC=38.49µM) - Escherichia coli NBRC 3301 (MIC=38.49µM) -

NOTE: No activity against Leu. mesenteroides TK41401 & Staphylococcus aureus ssp. aureus ATCC 12600 (>38.49 µM).

Uniprot and PDB links

UniProt Entry: G5ELQ0

PDB EntryUnknown

[Ref. 1] | View abstract | Export citation
PROTEIN SEQUENCE, FUNCTION AND BIOPHYSICOCHEMICAL PROPERTIES
PubMed=21948835;DOI=10.1128/AEM.06348-11
Masuda Y., Ono H., Kitagawa H., Ito H., Mu F., Sawa N., Zendo T., Sonomoto K.
"Identification and Characterization of Leucocyclicin Q, a Novel Cyclic Bacteriocin Produced by Leuconostoc mesenteroides TK41401.", Appl. Environ. Microbiol. (2011).
Loading...
End Note
Reference Manager
BibTeX
Gene structure
genome of Leucocyclicin Q

Gene idNameDescriptionLocation
BACGene942lcyRputative trancriptional regulatorcomplement(181..936)
BACGene943lcyQleucocyclicin Q1181..1372
BACGene944lcyBmembrane protein1481..2131
BACGene945lcyCimmunity protein2138..2872
BACGene946lcyDimmunity protein membrane protein2856..3383
lcyRlcyQlcyBlcyClcyD
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 
          |          |          |          |          |          |          | 
 MFLVNQLGIS KSLANTILGA IAVGNLASWL LALVPGPGWA TKAALATAET IVKHEGKAAA IAW

precursor
Wheel representation
wheel representation of Leucocyclicin Q
Composition
Amino acidCountPercent
A1422.22 %
C00.00 %
D00.00 %
E23.17 %
F11.59 %
G69.52 %
H11.59 %
I57.94 %
K46.35 %
L914.29 %
M11.59 %
N34.76 %
P23.17 %
Q11.59 %
R00.00 %
S34.76 %
T46.35 %
V46.35 %
W34.76 %
Y00.00 %
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids CDRY
Common amino acids A
Mass (Da) 6412.23
Net charge +3
Isoelectric point 10.33
Basic residues 5
Acidic residues 2
Hydrophobic residues 36
Polar residues 16
Aliphatic residues 18
Tiny residues 23
Boman Index 41.92
Hydropathy Index 0.795
Aliphatic Index 127.3
Instability Index 6.4 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 16500 M-1 cm-1
Absorbance 280nm 266.13