Bacteriocin: staphylococcin C55 alpha
Accession: BAC194
Classification
Class: Lantibiotic (two-peptide)
Genetics
Gene: ORFNames=SAP057A_040
Producer and target organisms
Producer Organism: Staphylococcus aureus [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacillalesStaphylococcus
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: Q9S4D3
PDB EntryUnknown
NUCLEOTIDE SEQUENCE, STRAIN=C55.
MEDLINE=99346225;PubMed=10417203;
Navaratna M.A., Sahl H.G., Tagg J.R.
"Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene.", Infect. Immun. 67:4268-4271(1999).
MEDLINE=99346225;PubMed=10417203;
Navaratna M.A., Sahl H.G., Tagg J.R.
"Identification of genes encoding two-component lantibiotic production in Staphylococcus aureus C55 and other phage group II S. aureus strains and demonstration of an association with the exfoliative toxin B gene.", Infect. Immun. 67:4268-4271(1999).
[Ref. 2]
NUCLEOTIDE SEQUENCE, STRAIN=C55.
Navaratna M.A.D.B., Tagg J.R., Sahl H.-G.
"", Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
Navaratna M.A.D.B., Tagg J.R., Sahl H.-G.
"", Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
[Ref. 3]
NUCLEOTIDE SEQUENCE, STRAIN=3049; PLASMID=SAP057A.
Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.
"", Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B.
"", Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
[Ref. 4]
NUCLEOTIDE SEQUENCE, STRAIN=3049; PLASMID=SAP057A.
Summers A.O., Shearer J., Wireman J.
"", Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
Summers A.O., Shearer J., Wireman J.
"", Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
NUCLEOTIDE SEQUENCE, STRAIN=TY4; PLASMID=ETB plasmid.
MEDLINE=21562640;PubMed=11705958;DOI=10.1128/IAI.69.12.7760-7771.2001
Yamaguchi T., Hayashi T., Takami H., Ohnishi M., Murata T., Nakayama K., Asakawa K., Ohara M., Komatsuzawa H., Sugai M.
"Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C.", Infect. Immun. 69:7760-7771(2001).
MEDLINE=21562640;PubMed=11705958;DOI=10.1128/IAI.69.12.7760-7771.2001
Yamaguchi T., Hayashi T., Takami H., Ohnishi M., Murata T., Nakayama K., Asakawa K., Ohara M., Komatsuzawa H., Sugai M.
"Complete nucleotide sequence of a Staphylococcus aureus exfoliative toxin B plasmid and identification of a novel ADP-ribosyltransferase, EDIN-C.", Infect. Immun. 69:7760-7771(2001).
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Protein sequence
| ........10 ........20 ........30 ........40 | | | | CSTNTFSLSD YWGNKGNWCT ATHECMSWCK |
Wheel representation
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 1 | 3.33 % |
| C | 4 | 13.33 % |
| D | 1 | 3.33 % |
| E | 1 | 3.33 % |
| F | 1 | 3.33 % |
| G | 2 | 6.67 % |
| H | 1 | 3.33 % |
| I | 0 | 0.00 % |
| K | 2 | 6.67 % |
| L | 1 | 3.33 % |
| M | 1 | 3.33 % |
| N | 3 | 10.00 % |
| P | 0 | 0.00 % |
| Q | 0 | 0.00 % |
| R | 0 | 0.00 % |
| S | 4 | 13.33 % |
| T | 4 | 13.33 % |
| V | 0 | 0.00 % |
| W | 3 | 10.00 % |
| Y | 1 | 3.33 % |
Hydrophobicity
Composition
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | IPQRV |
| Common amino acids | STC |
| Mass (Da) | 3 |
| Net charge | +1 |
| Isoelectric point | 7.12 |
| Basic residues | 3 |
| Acidic residues | 2 |
| Hydrophobic residues | 6 |
| Polar residues | 18 |
| Aliphatic residues | 1 |
| Tiny residues | 7 |
| Boman Index | -49.18 |
| Hydropathy Index | -0.633 |
| Aliphatic Index | 16.33 |
| Instability Index | 46 (unstable) |
| Half Life |
Mammalian : 1.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 18240 M-1 cm-1 |
| Absorbance 280nm | 628.97 |