Enterocin Xbeta

Accession: BAC190

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Bacteriocin: Enterocin Xbeta

Accession: BAC190
Classification
Class: Class IIb
Genetics
Gene: enxB
Producer and target organisms

Producer Organism: Enterococcus faecium (Streptococcus faecium) [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsUnknown error type: [8] Uninitialized string offset: -1
Gram-positive: - Enterococcus faecalis JCM 5803 (MIC=813nM) - Enterococcus faecalis OU510 (MIC=813nM) - Enterococcus faecium TUA 1344L (MIC=813nM) - Enterococcus hirae ATCC 10541 (MIC=406nM) - Lactobacillus plantarum ATCC 14917 (MIC=813nM) - Lactobacillus sakei ssp. sakei JCM 1157 (MIC=102nM) - Bacillus circulans JCM 2504 (MIC=3250nM) - Bacillus coagulans JCM 2257 (MIC=3250nM) - Bacillus subtilis JCM 1465 (MIC=3250nM) - Listeria innocua ATCC 33090 (MIC=3250nM)

Description
entXα and entXβ encode a double-glycine-type prepeptide with an 18-residue leader sequence, representing the typical structure of class II bacteriocin prepeptides.
[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE, STRAIN=KU-B5.
PubMed=20418437;DOI=10.1128/AEM.02264-09
Hu C.-B., Malaphan W., Zendo T., Nakayama J., Sonomoto K.
"Enterocin X, a novel two-peptide bacteriocin from Enterococcus faecium KU-B5, has an antibacterial spectrum entirely different from those of its component peptides.", Appl. Environ. Microbiol. 76:4542-4545(2010).
[Ref. 2]
NUCLEOTIDE SEQUENCE, STRAIN=KU-B5.
Hu C., Malaphan W., Zendo T., Nakayama J., Sonomoto K.
"", Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
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Gene structure
genome of Enterocin Xbeta

Gene idNameDescriptionLocation
BACGene878hypothetical protein ORFX1; hypothetical protein298..444
BACGene879hypothetical protein ORFX2; hypothetical proteincomplement(434..766)
BACGene880hypothetical protein ORFX3; hypothetical proteincomplement(763..978)
BACGene881enxAenterocin Xalpha prepeptide Alpha subunit of enterocin X (two-peptide bacteriocin)1255..1431
BACGene882enxBenterocin Xbeta Beta subunit of enterocin X (two-peptide bacteriocin)1450..1617
BACGene883enxBhypothetical protein ORFX4; hypothetical protein1732..1953
enxAenxBenxB
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 IAPIIVAGLG YLVKDAWDHS DQIISGFKKG WNGGRRK
Wheel representation
wheel representation of Enterocin Xbeta
Composition
Amino acidCountPercent
A38.11 %
C00.00 %
D38.11 %
E00.00 %
F12.70 %
G616.22 %
H12.70 %
I513.51 %
K410.81 %
L25.41 %
M00.00 %
N12.70 %
P12.70 %
Q12.70 %
R25.41 %
S25.41 %
T00.00 %
V25.41 %
W25.41 %
Y12.70 %
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids CEMT
Common amino acids G
Mass (Da) 4
Net charge +4
Isoelectric point 10.48
Basic residues 7
Acidic residues 3
Hydrophobic residues 15
Polar residues 10
Aliphatic residues 9
Tiny residues 11
Boman Index -40.75
Hydropathy Index -0.197
Aliphatic Index 97.57
Instability Index 24.64 (stable)
Half Life Mammalian : 20 hour
Yeast : 30 min
E. coli : >10 hour
Extinction Coefficient 12490 M-1 cm-1
Absorbance 280nm 346.94