Enterocin E-760

Accession: BAC174

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Bacteriocin: Enterocin E-760

Accession: BAC174

Classification

Class: class IIb

Genetics

Gene: ~~Unidentified~~

Producer and target organisms

Producer Organism: Enterococcus sp [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsGram-positive bacteria: Staphylococcus aureus - Staphylococcus epidermidis - Listeria monocytogenes 9-72 -

Gram-negative bacteria: Campylobacter sp - Salmonella enterica serovar Enteritidis 1 - Salmonella enterica serovar Enteritidis 4 - Salmonella enterica serovar Enteritidis 204 - Salmonella enterica serovar Enteritidis 237 - Salmonella enterica serovar Choleraesuis 434/4 - Salmonella enterica serovar Choleraesuis 370 - Salmonella enterica serovar Typhimurium 383/60 - Salmonella enterica serovar Typhimurium 320 - Salmonella enterica serovar Gallinarum biovar Pullorum - Escherichia coli HB101 - Escherichia coli C600 - Escherichia coli O157:H7 Y-63 - Escherichia coli O157:H7 G-3 - Escherichia coli O157:H7 OD-3 - Escherichia coli O157:H7 T-39 - Yersinia enterocolitica 03 - Yersinia enterocolitica 09 - Yersinia enterocolitica 04 - Yersinia pseudotuberculosis ser 4 - Yersinia pseudotuberculosis 14 - Citrobacter freundii - Klebsiella pneumoniae - Shigella dysenteriae - Campylobacter jejuni L4

Uniprot and PDB links

UniProt Entry: P85147

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

[1]PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULARLOCATION, AND MASS SPECTROMETRY.STRAIN=NRRL B-30745
PubMed=18086839;DOI=10.1128/AAC.01569-06
Line J.E., Svetoch E.A., Eruslanov B.V., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Levchuk V.P., Svetoch O.E., Seal B., Siragusa G., Stern N.J.
"Isolation and purification of enterocin E-760 with broad antimicrobial activity against Gram-positive and Gram-negative bacteria.", Antimicrob. Agents Chemother. 52:1094-1100(2008)

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60 ........70
| | | | | | |
NRWYCNSAAG GVGGAAVCGL AGYVGEAKEN IAGEVRKGWG MAGGFTHNKA CKSFPGSGWA SG

Wheel representation

Protein sequence annotations

Feature	Position(s)	Length	Description
CHAIN	1↔62	62	Enterocin E-760. Feature identifier = PRO_0000320547.

Composition

Amino acid	Count	Percent
A	10	16.13 %
C	3	4.84 %
D	0	0.00 %
E	3	4.84 %
F	2	3.23 %
G	15	24.19 %
H	1	1.61 %
I	1	1.61 %
K	4	6.45 %
L	1	1.61 %
M	1	1.61 %
N	4	6.45 %
P	1	1.61 %
Q	0	0.00 %
R	2	3.23 %
S	4	6.45 %
T	1	1.61 %
V	4	6.45 %
W	3	4.84 %
Y	2	3.23 %

Hydrophobicity

Composition

Formula	C₂₆₉ H₄₀₃ N₈₁ O₈₀ S₄
Absent amino acids	DQ
Common amino acids	G
Mass (Da)	6198.95
Net charge	+4
Isoelectric point	8.91
Basic residues	7
Acidic residues	3
Hydrophobic residues	21
Polar residues	29
Aliphatic residues	6
Tiny residues	29
Boman Index	-42.8
Hydropathy Index	-0.18
Aliphatic Index	47.42
Instability Index	42.56 (unstable)
Half Life	Mammalian : 1.4 hour Yeast : 3 min E. coli : >10 hour
Extinction Coefficient	19480 M^-1 cm^-1
Absorbance 280nm	321.39