Bacteriocin: Lacticin Z
Accession: BAC170
Producer Organism: Lactococcus lactis QU 14 [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeLactococcus
Target organismsBacillus subtilis - Bacillus circulans - Bacillus coagulans - Lactobacillus sakei - Lactobacillus plantarum - Lactobacillus coryniformis - Lactobacillus kimchii - Lactobacillus casei - Lactobacillus acidophilus - Lactobacillus brevis - Enterococcus faecium - Enterococcus mundtii - Enterococcus hirae - Enterococcus durans - Pediococcus pentosaceus - Pediococcus acidilactici - Pediococcus dextrinicus - Lactococcus lactis ssp lactis - Lactococcus rafinolactis - lactococcus lactis ssp cremoris - lactococcus lactis - Leuconostoc mesenteroides ssp mesenteroides - Listeria innocua - Micrococcus luteus - Streptococcus mutans - Streptococcus bovis - Streptococcus salivarius -
note: not active against Escherichia coli
UniProt Entry: A7M6Q0
PDB EntryUnknown
PubMed=17690480;DOI=10.1271/bbb.70169
Iwatani S., Zendo T., Yoneyama F., Nakayama J., Sonomoto K.
"Characterization and Structure Analysis of a Novel Bacteriocin,Lacticin Z, Produced by Lactococcus lactis QU 14.";", Biosci. Biotechnol. Biochem. 71:1984-1992(2007)
| Gene id | Name | Description | Location |
| BACGene794 | orf1z | hypothetical protein | complement(810..1367) |
| BACGene795 | orf2z | putative transcriptional regulator | complement(2064..2642) |
| BACGene796 | lnqZ | lacticin Z | 3087..3248 |
| BACGene797 | orf3z | membrane protein | 3334..3582 |
| BACGene798 | orf4z | membrane protein | 3551..4069 |
| BACGene799 | orf5z | membrane protein | 4032..5360 |
| BACGene800 | orf6z | ABC-2 type transporter | 5333..5995 |
| BACGene801 | orf7z | ATP-binding protein | 6079..6870 |
| BACGene802 | orf8z | prophage ps1 protein 16 | complement(7065..7649) |
| BACGene803 | orf9z | prophage ps1 protein 15 | complement(7653..7997) |
| ........10 ........20 ........30 ........40 ........50 ........60 | | | | | | MAGFLKVVQI LAKYGSKAVQ WAWANKGKIL DWINAGQAID WVVEKIKQIL GIK |
| Amino acid | Count | Percent |
|---|---|---|
| A | 7 | 13.21 % |
| C | 0 | 0.00 % |
| D | 2 | 3.77 % |
| E | 1 | 1.89 % |
| F | 1 | 1.89 % |
| G | 5 | 9.43 % |
| H | 0 | 0.00 % |
| I | 7 | 13.21 % |
| K | 8 | 15.09 % |
| L | 4 | 7.55 % |
| M | 1 | 1.89 % |
| N | 2 | 3.77 % |
| P | 0 | 0.00 % |
| Q | 4 | 7.55 % |
| R | 0 | 0.00 % |
| S | 1 | 1.89 % |
| T | 0 | 0.00 % |
| V | 5 | 9.43 % |
| W | 4 | 7.55 % |
| Y | 1 | 1.89 % |
| Formula | C281
H447
N71
O68
S1 |
| Absent amino acids | CHPRT |
| Common amino acids | KAI |
| Mass (Da) | 5959.09 |
| Net charge | +5 |
| Isoelectric point | 10.63 |
| Basic residues | 8 |
| Acidic residues | 3 |
| Hydrophobic residues | 28 |
| Polar residues | 9 |
| Aliphatic residues | 16 |
| Tiny residues | 13 |
| Boman Index | -1.29 |
| Hydropathy Index | 0.28 |
| Aliphatic Index | 121.51 |
| Instability Index | 8.68 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 23490 M-1 cm-1 |
| Absorbance 280nm | 451.73 |