Lacticin Q

Accession: BAC169

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Bacteriocin: Lacticin Q

Accession: BAC169
Classification
Class: Unclassified
Genetics
Gene: lnqQ
Producer and target organisms

Producer Organism: Lactococcus lactis QU 5 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Target organismsBrochothrix campestris ATCC 43754 (MIC=2µM) - Carnobacterium divergens LV13 (MIC=2µM) - Carnobacterium maltaromaticum UAL26 (MIC=1µM) - Carnobacterium maltaromaticum UAL26 (pMG36c-cclBITCDA) (MIC=16µM) - Enterococcus faecalis ATCC 7080 (MIC=32µM) - Enterococcus faecium BFE900 (MIC=4µM) - Lactobacillus acidophilus M46 (MIC=0.5µM) - Lactobacillus sakei UAL1218 (MIC=0.5µM) - Lactococcus lactis ATCC 19257 (MIC=0.06µM) - Staphylococcus aureus ATCC 29213 (MIC=32µM) - Staphylococcus aureus ATCC 6538 (MIC=8µM)

[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE
PubMed=17351096;
Fujita K., Ichimasa S., Zendo T., Koga S., Yoneyama F., Nakayama J., Sonomoto K.
"Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria", Appl. Environ. Microbiol. 73:2871-2877(2007)
[Ref. 2] | View abstract | Export citation
STRUCTURE
PubMed=26771761;DOI=10.1021/acs.biochem.5b01306
Acedo J.Z., van Belkum M.J., Lohans C.T., Towle K.M., Miskolzie M., Vederas J.C.
"Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.", Biochemistry 2016, ():.
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Gene structure
genome of Lacticin Q

Gene idNameDescriptionLocation
BACGene782collagen-binding protein orf1993..2873
BACGene783putative transcriptional regulator orf2complement(3827..4402)
BACGene784lnqQlacticin Q4840..5001
BACGene785lnqQmembrane permease protein orf35078..5317
BACGene786lnqQmembrane-franked domain protein orf45295..5774
BACGene787lnqQmembrane-franked domain protein orf55764..7062
BACGene788lnqQABC-2 type transporter orf67062..7739
BACGene789lnqQABC transporter, ATP-binding protein orf77806..8600
BACGene790lnqQputative transcriptional regulator orf8complement(10192..10872)
BACGene791lnqQreplication protein orf912793..14124
BACGene792lnqQDNA integrase/recombinase orf1014523..15650
BACGene793lnqQATP/GTP binding protein orf11complement(15711..16553)
lnqQlnqQlnqQlnqQlnqQlnqQlnqQlnqQlnqQlnqQ
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 
          |          |          |          |          |          | 
 AGFLKVVQLL AKYGSKAVQW AWANKGKILD WLNAGQAIDW VVSKIKQILG IK
Wheel representation
wheel representation of Lacticin Q
3D Structure

View PDB entry: 2N8P

Composition
Amino acidCountPercent
A713.46 %
C00.00 %
D23.85 %
E00.00 %
F11.92 %
G59.62 %
H00.00 %
I59.62 %
K815.38 %
L611.54 %
M00.00 %
N23.85 %
P00.00 %
Q47.69 %
R00.00 %
S23.85 %
T00.00 %
V59.62 %
W47.69 %
Y11.92 %
Hydrophobicity

Composition
Formula C279 H445 N71 O67 S1
Absent amino acids CEHPRT
Common amino acids KA
Mass (Da) 5917.05
Net charge +6
Isoelectric point 10.84
Basic residues 8
Acidic residues 2
Hydrophobic residues 28
Polar residues 10
Aliphatic residues 16
Tiny residues 14
Boman Index 2.12
Hydropathy Index 0.3
Aliphatic Index 121.51
Instability Index 7.38 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 23490 M-1 cm-1
Absorbance 280nm 451.73