Bacteriocin: duramycin-C
Accession: BAC152
Classification
Class: lanthionin
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Streptomyces griseoluteus [Gram-positive]
Taxonomy: Bacteria
ActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: P36503
PDB EntryUnknown
STRUCTURE by NMR of duramycin-C
PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216(2):419-28(1993)
PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216(2):419-28(1993)
structure of duramycin-C
PubMed=2125590;
Fredenhagen A., Fendrich G., Märki F., Märki W., Gruner J., Raschdorf F., Peter HH.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. (Tokyo) 43(11):1403-1412(1990
PubMed=2125590;
Fredenhagen A., Fendrich G., Märki F., Märki W., Gruner J., Raschdorf F., Peter HH.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. (Tokyo) 43(11):1403-1412(1990
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Protein sequence
| ........10 ........20 | | CANSCSYGPL TWSCDGNTK |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔19 | 19 | Lantibiotic duramycin-C. Feature identifier = PRO_0000043972. |
| Cross-link | 1↔18 | 18 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 4↔14 | 11 | Lanthionine (Ser-Cys). |
| Cross-link | 5↔11 | 7 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 6↔19 | 14 | Lysinoalanine (Ser-Lys). |
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 1 | 5.26 % |
| C | 3 | 15.79 % |
| D | 1 | 5.26 % |
| E | 0 | 0.00 % |
| F | 0 | 0.00 % |
| G | 2 | 10.53 % |
| H | 0 | 0.00 % |
| I | 0 | 0.00 % |
| K | 1 | 5.26 % |
| L | 1 | 5.26 % |
| M | 0 | 0.00 % |
| N | 2 | 10.53 % |
| P | 1 | 5.26 % |
| Q | 0 | 0.00 % |
| R | 0 | 0.00 % |
| S | 3 | 15.79 % |
| T | 2 | 10.53 % |
| V | 0 | 0.00 % |
| W | 1 | 5.26 % |
| Y | 1 | 5.26 % |
Hydrophobicity
Composition
| Formula | C82
H123
N23
O30
S3 |
| Absent amino acids | EFHIMQRV |
| Common amino acids | CS |
| Mass (Da) | 2025.5 |
| Net charge | 0 |
| Isoelectric point | 6 |
| Basic residues | 1 |
| Acidic residues | 1 |
| Hydrophobic residues | 3 |
| Polar residues | 13 |
| Aliphatic residues | 1 |
| Tiny residues | 6 |
| Boman Index | -28.25 |
| Hydropathy Index | -0.51 |
| Aliphatic Index | 25.79 |
| Instability Index | 32.61 (stable) |
| Half Life |
Mammalian : 1.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 6990 M-1 cm-1 |
| Absorbance 280nm | 395.28 |