Bacteriocin: duramycin (duramycin-B) (Leucopeptin)
Accession: BAC151
Classification
Class: Lantibiotic B
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Streptomyces griseoverticillatus [Gram-positive]
Taxonomy: Bacteria
ActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: P36504
PDB EntryUnknown
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Protein sequence
| ........10 ........20 | | CKQSCSFGPF TFVCDGNTK |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| PEPTIDE | 1↔19 | 19 | Lantibiotic duramycin. Feature identifier = PRO_0000043970. |
| Cross-link | 1↔18 | 18 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 4↔14 | 11 | Lanthionine (Ser-Cys). |
| Cross-link | 5↔11 | 7 | Beta-methyllanthionine (Cys-Thr). |
| Cross-link | 6↔19 | 14 | Lysinoalanine (Ser-Lys). |
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 0 | 0.00 % |
| C | 3 | 15.79 % |
| D | 1 | 5.26 % |
| E | 0 | 0.00 % |
| F | 3 | 15.79 % |
| G | 2 | 10.53 % |
| H | 0 | 0.00 % |
| I | 0 | 0.00 % |
| K | 2 | 10.53 % |
| L | 0 | 0.00 % |
| M | 0 | 0.00 % |
| N | 1 | 5.26 % |
| P | 1 | 5.26 % |
| Q | 1 | 5.26 % |
| R | 0 | 0.00 % |
| S | 2 | 10.53 % |
| T | 2 | 10.53 % |
| V | 1 | 5.26 % |
| W | 0 | 0.00 % |
| Y | 0 | 0.00 % |
Hydrophobicity
Composition
| Formula | C89
H133
N23
O28
S3 |
| Absent amino acids | AEHILMRWY |
| Common amino acids | CF |
| Mass (Da) | 2087.65 |
| Net charge | +1 |
| Isoelectric point | 8.04 |
| Basic residues | 2 |
| Acidic residues | 1 |
| Hydrophobic residues | 4 |
| Polar residues | 10 |
| Aliphatic residues | 1 |
| Tiny residues | 4 |
| Boman Index | -25.24 |
| Hydropathy Index | -0.19 |
| Aliphatic Index | 15.26 |
| Instability Index | 80.05 (unstable) |
| Half Life |
Mammalian : 1.2 hour Yeast : > 20 hour E. coli : >10 hour |
| Extinction Coefficient | 0 M-1 cm-1 |
| Absorbance 280nm | 6.94 |