Bacteriocin: Ubericin A

Default view

Bacteriocin: Ubericin A

Accession: BAC150

Classification
Class: Class IIa
Genetics
Gene: ubaA
Description
FUNCTION:
Heat-stable antibiotic with bacteriolytic activity against Listeria spp., Enterococcus hirae, Enterococcus faecalis ATCC 19433, S.bovis 83, S.uberis 42 and L.lactis.
SUBCELLULAR LOCATION: Secreted.
PTM: The disulfide bond is essential for the activity.
MASS SPECTROMETRY: Mass=5270.5; Mass_error=5.3; Method=MALDI;
Range=22-70; Source=PubMed:17933926;
SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
Uniprot and PDB links

UniProt Entry: A9Q0M7

PDB EntryUnknown

NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 22-61, DISULFIDE BOND, AND MASS SPECTROMETRY.
PubMed=17933926;DOI=10.1128/AEM.01818-07
Heng N.C.K., Burtenshaw G.A., Jack R.W., Tagg J.R.
"Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis.", Appl. Environ. Microbiol. 73:7763-7766 (2007).
Loading...
End Note
Reference Manager
BibTeX
Gene structure
genome of Ubericin A

Gene idNameDescriptionLocation
BACGene680ubaAubericin A precursor peptide294..506
BACGene681ubaIubericin A immunity protein506..805
BACGene682fpgformamidopyrimidine-DNA glycosylase985..1806
BACGene683coaEdephospho-CoA kinase1803..2390
BACGene684coaEpredicted membrane protein unknown function; similar to Haso02000823 from Haemophilus somnus strain 2336;ORF12400..3035
BACGene685coaEhypothetical protein putative ATPase; ORF23161..3554
ubaAubaIfpgcoaEcoaEcoaE
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 KTVNYGNGLY CNQKKCWVNW SETATTIVNN SIMNGLTGGN AGWHSGGRA

Wheel representation
wheel representation of Ubericin A
Protein sequence annotations
Features of Ubericin A


FeaturePosition(s)LengthDescription
CHAIN1↔4949
Bacteriocin ubericin-A.
Feature identifier = PRO_5000298104.
DISULFID11↔166
Composition
Hydrophobicity

Composition
Formula C227 H347 N69 O71 S3
Absent amino acids DFP
Common amino acids GN
Mass (Da) 5293.67
Net charge +4
Isoelectric point 9.35
Basic residues 5
Acidic residues 1
Hydrophobic residues 13
Polar residues 28
Aliphatic residues 7
Tiny residues 14
Boman Index -68.38
Hydropathy Index -0.56
Aliphatic Index 55.71
Instability Index 10.76 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 19480 M-1 cm-1
Absorbance 280nm 408.44

Users comments for Ubericin A

No comments found

Login or register to submit a comment for Ubericin A.