Haloduracin Hal Beta

Accession: BAC140

Default view

Bacteriocin: haloduracin Hal beta

Accession: BAC140

Classification

Class: Lantibiotic (two-peptide)

Genetics

Gene: HalA2

Producer and target organisms

Producer Organism: Bacillus halodurans C-125 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesBacillaceaeBacillus

Target organisms~~Unavailable data~~

Description

under review

Related Entries

haloduracin Hal alpha

Uniprot and PDB links

UniProt Entry: ~~No entry found~~

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

PROTEIN SEQUENCE
PubMed=17085596;
McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.", Proc Natl Acad Sci U S A. 2006, 103(46):17243-8.

Protein sequence

........10 ........20 ........30 ........40
| | | |
GDVHAQTTWP CATVGVSVAL CPTTKCTSQC

Wheel representation

Composition

Amino acid	Count	Percent
A	3	10.00 %
C	4	13.33 %
D	1	3.33 %
E	0	0.00 %
F	0	0.00 %
G	2	6.67 %
H	1	3.33 %
I	0	0.00 %
K	1	3.33 %
L	1	3.33 %
M	0	0.00 %
N	0	0.00 %
P	2	6.67 %
Q	2	6.67 %
R	0	0.00 %
S	2	6.67 %
T	6	20.00 %
V	4	13.33 %
W	1	3.33 %
Y	0	0.00 %

Hydrophobicity

Composition

Formula	C₁₂₈ H₂₀₆ N₃₆ O₄₃ S₄
Absent amino acids	EFIMNRY
Common amino acids	T
Mass (Da)	3084.01
Net charge	+1
Isoelectric point	7.12
Basic residues	2
Acidic residues	1
Hydrophobic residues	9
Polar residues	14
Aliphatic residues	5
Tiny residues	7
Boman Index	-16.39
Hydropathy Index	0.257
Aliphatic Index	10.49
Instability Index	20.51 (stable)
Half Life	Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	5750 M^-1 cm^-1
Absorbance 280nm	198.28