Bacteriocin: haloduracin Hal alpha
Accession: BAC139
Classification
Class: Lantibiotic (two-peptide)
Genetics
Gene: HalA1
Producer and target organisms
Producer Organism: Bacillus halodurans C-125 [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacillalesBacillaceaeBacillus
Target organismsUnavailable data
Description
under review
Uniprot and PDB links
UniProt Entry: No entry found
PDB EntryUnknown
PROTEIN SEQUENCE
PubMed=17085596;
McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.", Proc Natl Acad Sci U S A. 2006, 103(46):17243-8.
PubMed=17085596;
McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA.
"Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic.", Proc Natl Acad Sci U S A. 2006, 103(46):17243-8.
Loading...
Protein sequence
| ........10 ........20 ........30 | | | CAWYNISCRL GNKGAYCTLT VECMPSCN |
Wheel representation
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 2 | 7.14 % |
| C | 5 | 17.86 % |
| D | 0 | 0.00 % |
| E | 1 | 3.57 % |
| F | 0 | 0.00 % |
| G | 2 | 7.14 % |
| H | 0 | 0.00 % |
| I | 1 | 3.57 % |
| K | 1 | 3.57 % |
| L | 2 | 7.14 % |
| M | 1 | 3.57 % |
| N | 3 | 10.71 % |
| P | 1 | 3.57 % |
| Q | 0 | 0.00 % |
| R | 1 | 3.57 % |
| S | 2 | 7.14 % |
| T | 2 | 7.14 % |
| V | 1 | 3.57 % |
| W | 1 | 3.57 % |
| Y | 2 | 7.14 % |
Hydrophobicity
Composition
| Formula | C130
H202
N36
O40
S6 |
| Absent amino acids | DFHQ |
| Common amino acids | C |
| Mass (Da) | 3 |
| Net charge | +1 |
| Isoelectric point | 7.81 |
| Basic residues | 2 |
| Acidic residues | 1 |
| Hydrophobic residues | 7 |
| Polar residues | 16 |
| Aliphatic residues | 4 |
| Tiny residues | 6 |
| Boman Index | -24.04 |
| Hydropathy Index | 0.107 |
| Aliphatic Index | 59.29 |
| Instability Index | 109.53 (unstable) |
| Half Life |
Mammalian : 1.2 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 8730 M-1 cm-1 |
| Absorbance 280nm | 323.33 |