Bacteriocin: acidocin B (AcdB)
Accession: BAC111
Classification
Class: Unclassified
Genetics
Gene: acdB
Producer and target organisms
Producer Organism: Lactobacillus acidophilus [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesLactobacillaceaeLactobacillus
Target organismsUnknown error type: [8] Uninitialized string offset: -1
Listeria monocytogenes - Clostridium sporogenes - Brochothrix thermosphacta - Lactobacillus fermentum - Lactobacillus delbrueckii subsp. bulgaricus -
NOTE: inactive against most other Lactobacillus species.
Uniprot and PDB links
UniProt Entry: Q48498
PDB Entry2MWR resolved by NMR
NUCLEOTIDE SEQUENCE, STRAIN=M46
MEDLINE=96004462;PubMed=7551031;
Leer R., van der Vossen J., van Giezen M., van Noort H., Pouwels P.
"Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus.", Microbiol. 141:1629-1635(1995).
MEDLINE=96004462;PubMed=7551031;
Leer R., van der Vossen J., van Giezen M., van Noort H., Pouwels P.
"Genetic analysis of acidocin B, a novel bacteriocin produced by Lactobacillus acidophilus.", Microbiol. 141:1629-1635(1995).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene520 | 858..1040 | ||
| BACGene521 | acdB | acidocin B bacteriocin | 1147..1422 |
| BACGene522 | acdB | 1506..1850 |
Protein sequence
| ........10 ........20 ........30 ........40 ........50 ........60 | | | | | | NIYWIADQFG IHLATGTARK LLDAVASGAS LGTAFAAILG VTLPAWALAA AGALGATAA |
Wheel representation
3D Structure
View PDB entry: 2MWR
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 18 | 30.51 % |
| C | 0 | 0.00 % |
| D | 2 | 3.39 % |
| E | 0 | 0.00 % |
| F | 2 | 3.39 % |
| G | 7 | 11.86 % |
| H | 1 | 1.69 % |
| I | 4 | 6.78 % |
| K | 1 | 1.69 % |
| L | 8 | 13.56 % |
| M | 0 | 0.00 % |
| N | 1 | 1.69 % |
| P | 1 | 1.69 % |
| Q | 1 | 1.69 % |
| R | 1 | 1.69 % |
| S | 2 | 3.39 % |
| T | 5 | 8.47 % |
| V | 2 | 3.39 % |
| W | 2 | 3.39 % |
| Y | 1 | 1.69 % |
Hydrophobicity
Composition
| Formula | C265
H417
N69
O74
|
| Absent amino acids | CEM |
| Common amino acids | A |
| Mass (Da) | 5772.73 |
| Net charge | +1 |
| Isoelectric point | 7.54 |
| Basic residues | 3 |
| Acidic residues | 2 |
| Hydrophobic residues | 36 |
| Polar residues | 16 |
| Aliphatic residues | 14 |
| Tiny residues | 27 |
| Boman Index | 42.36 |
| Hydropathy Index | 0.96 |
| Aliphatic Index | 119.66 |
| Instability Index | 9.19 (stable) |
| Half Life |
Mammalian : 1.4 hour Yeast : 3 min E. coli : >10 hour |
| Extinction Coefficient | 12490 M-1 cm-1 |
| Absorbance 280nm | 215.34 |