Acidocin A

Accession: BAC107

Default view

Bacteriocin: Acidocin A

Accession: BAC107

Classification

Class: class IIA/YGNGV

Genetics

Gene: acdA

Producer and target organisms

Producer Organism: Lactobacillus acidophilus [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsLactobacillus - Streptococcus - Pediococcus - Listeria monocytogenes - Bacillus subtilis - Enterococcus

Uniprot and PDB links

UniProt Entry: Q48496

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE, STRAIN=TK9201
MEDLINE=95314239;PubMed=7793908;
Kanatani K., Oshimura M., Sano K.
"Isolation and characterization of acidocin A and cloning of the bacteriocin gene from Lactobacillus acidophilus.", Appl. Environ. Microbiol. 61:1061-1067(1995).

Gene structure

Gene id	Name	Description	Location
BACGene497	acdA	acidocin A bacteriocin	142..387
BACGene498	acdA	ORF2 unknown	416..583

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60
| | | | | |
KTYYGTNGVH CTKKSLWGKV RLKNVIPGTL CRKQSLPIKQ DLKILLGWAT GAFGKTFH

Wheel representation

Protein sequence annotations

Feature	Position(s)	Length	Description
CHAIN	1↔58	58	mature acidocin A. Feature identifier = PRO_5000139827.

Composition

Amino acid	Count	Percent
A	2	3.45 %
C	2	3.45 %
D	1	1.72 %
E	0	0.00 %
F	2	3.45 %
G	7	12.07 %
H	2	3.45 %
I	3	5.17 %
K	9	15.52 %
L	7	12.07 %
M	0	0.00 %
N	2	3.45 %
P	2	3.45 %
Q	2	3.45 %
R	2	3.45 %
S	2	3.45 %
T	6	10.34 %
V	3	5.17 %
W	2	3.45 %
Y	2	3.45 %

Hydrophobicity

Composition

Formula	C₂₉₉ H₄₈₁ N₈₃ O₇₅ S₂
Absent amino acids	EM
Common amino acids	K
Mass (Da)	6521.72
Net charge	+12
Isoelectric point	10.94
Basic residues	13
Acidic residues	1
Hydrophobic residues	19
Polar residues	21
Aliphatic residues	13
Tiny residues	11
Boman Index	-59.99
Hydropathy Index	-0.3
Aliphatic Index	85.69
Instability Index	23.99 (stable)
Half Life	Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min
Extinction Coefficient	14105 M^-1 cm^-1
Absorbance 280nm	247.46