Bacteriocin: Plantaricin 423
Accession: BAC104
Classification
Class: class IIa
Genetics
Gene: plaA
Producer and target organisms
Producer Organism: Lactobacillus plantarum [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesLactobacillaceaeLactobacillus
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: Q93FV7
PDB EntryUnknown
NUCLEOTIDE SEQUENCE.
MEDLINE=22311147;PubMed=12423916;DOI=10.1016/S0168-1605(02)00164-2
Van Reenen C.A., Chikindas M.L., Van Zyl W.H., Dicks L.M.
"Characterization and heterologous expression of a class IIa bacteriocin, plantaricin 423 from Lactobacillus plantarum 423, in Saccharomyces cerevisiae.", Int. J. Food Microbiol. 81:29-40(2003).
MEDLINE=22311147;PubMed=12423916;DOI=10.1016/S0168-1605(02)00164-2
Van Reenen C.A., Chikindas M.L., Van Zyl W.H., Dicks L.M.
"Characterization and heterologous expression of a class IIa bacteriocin, plantaricin 423 from Lactobacillus plantarum 423, in Saccharomyces cerevisiae.", Int. J. Food Microbiol. 81:29-40(2003).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene471 | plaA | prebacteriocin 423 | 400..570 |
| BACGene472 | plaB | putative immunity protein | 615..944 |
| BACGene473 | plaC | accessory protein similar to pedC of pediocin PA-1 | 1187..1711 |
| BACGene474 | plaD | ABC translocator similar to pedD of pediocin PA-1 | 1810..3984 |
| BACGene475 | plaD | RepB | complement(4213..5025) |
| BACGene476 | plaD | mobilization protein | complement(6450..7535) |
Protein sequence
| ........10 ........20 ........30 ........40 | | | | KYYGNGVTCG KHSCSVNWGQ AFSCSVSHLA NFGHGKC |
Wheel representation
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 2 | 5.41 % |
| C | 4 | 10.81 % |
| D | 0 | 0.00 % |
| E | 0 | 0.00 % |
| F | 2 | 5.41 % |
| G | 6 | 16.22 % |
| H | 3 | 8.11 % |
| I | 0 | 0.00 % |
| K | 3 | 8.11 % |
| L | 1 | 2.70 % |
| M | 0 | 0.00 % |
| N | 3 | 8.11 % |
| P | 0 | 0.00 % |
| Q | 1 | 2.70 % |
| R | 0 | 0.00 % |
| S | 5 | 13.51 % |
| T | 1 | 2.70 % |
| V | 3 | 8.11 % |
| W | 1 | 2.70 % |
| Y | 2 | 5.41 % |
Hydrophobicity
Composition
| Formula | C170
H249
N51
O50
S4 |
| Absent amino acids | DEIMPR |
| Common amino acids | G |
| Mass (Da) | 3954.01 |
| Net charge | +6 |
| Isoelectric point | 8.67 |
| Basic residues | 6 |
| Acidic residues | 0 |
| Hydrophobic residues | 9 |
| Polar residues | 21 |
| Aliphatic residues | 4 |
| Tiny residues | 13 |
| Boman Index | -36.23 |
| Hydropathy Index | -0.278 |
| Aliphatic Index | 6.51 |
| Instability Index | 2.68 (stable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 8730 M-1 cm-1 |
| Absorbance 280nm | 242.5 |