Bacteriocin: salivaricin A
Accession: BAC099
Classification
Class: Lantibiotic
Genetics
Gene: salA; OrderedLocusNames=M28_Spy1621
Producer and target organisms
Producer Organism: Streptococcus pyogenes serotype M28 [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeStreptococcus
Target organismsUnavailable data
Description
Annotated by homology to Salivaricin A (BAC016).
Uniprot and PDB links
UniProt Entry: Q48RC9
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], STRAIN=MGAS6180 / Serotype M28
PubMed=16088825;DOI=10.1086/430618
Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.", J. Infect. Dis. 192:760-770(2005).
PubMed=16088825;DOI=10.1086/430618
Green N.M., Zhang S., Porcella S.F., Nagiec M.J., Barbian K.D., Beres S.B., Lefebvre R.B., Musser J.M.
"Genome sequence of a serotype M28 strain of group A Streptococcus: potential new insights into puerperal sepsis and bacterial disease specificity.", J. Infect. Dis. 192:760-770(2005).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene417 | salA | lantibiotic salivaricin A | complement(1625261..1625416) |
Protein sequence
| ........10 ........20 ........30 | | | KKGSGWFATI TDDCPNSVFV CC |
Wheel representation
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 1 | 4.55 % |
| C | 3 | 13.64 % |
| D | 2 | 9.09 % |
| E | 0 | 0.00 % |
| F | 2 | 9.09 % |
| G | 2 | 9.09 % |
| H | 0 | 0.00 % |
| I | 1 | 4.55 % |
| K | 2 | 9.09 % |
| L | 0 | 0.00 % |
| M | 0 | 0.00 % |
| N | 1 | 4.55 % |
| P | 1 | 4.55 % |
| Q | 0 | 0.00 % |
| R | 0 | 0.00 % |
| S | 2 | 9.09 % |
| T | 2 | 9.09 % |
| V | 2 | 9.09 % |
| W | 1 | 4.55 % |
| Y | 0 | 0.00 % |
Hydrophobicity
Composition
| Formula | C104
H156
N26
O32
S3 |
| Absent amino acids | EHLMQRY |
| Common amino acids | C |
| Mass (Da) | 2387.08 |
| Net charge | 0 |
| Isoelectric point | 6.11 |
| Basic residues | 2 |
| Acidic residues | 2 |
| Hydrophobic residues | 7 |
| Polar residues | 10 |
| Aliphatic residues | 3 |
| Tiny residues | 5 |
| Boman Index | -18.3 |
| Hydropathy Index | -0.15 |
| Aliphatic Index | 48.64 |
| Instability Index | 20.05 (stable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 5500 M-1 cm-1 |
| Absorbance 280nm | 267.86 |