Bacteriocin: Divergicin A
Accession: BAC086
Classification
Class: Class IIc
Genetics
Gene: dvnA
Producer and target organisms
Producer Organism: Carnobacterium divergens [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesCarnobacteriaceaeCarnobacterium
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: Q3SAX6
PDB EntryUnknown
NUCLEOTIDE SEQUENCE, STRAIN=LV13
MEDLINE=95286495;PubMed=7768812;
Worobo R.W., Van Belkum M.J., Sailer M., Roy K.L., Vederas J.C., Stiles M.E.
"A signal peptide secretion-dependent bacteriocin from Carnobacterium divergens.", J. Bacteriol. 177:3143-3149(1995).
MEDLINE=95286495;PubMed=7768812;
Worobo R.W., Van Belkum M.J., Sailer M., Roy K.L., Vederas J.C., Stiles M.E.
"A signal peptide secretion-dependent bacteriocin from Carnobacterium divergens.", J. Bacteriol. 177:3143-3149(1995).
NUCLEOTIDE SEQUENCE, STRAIN=LV13
PubMed=16385127;DOI=10.1099/mic.0.28294-0
van Belkum M.J., Stiles M.E.
"Characterization of the theta-type plasmid pCD3.4 from Carnobacterium divergens, and modulation of its host range by RepA mutation.", Microbiology 152:171-178(2006).
PubMed=16385127;DOI=10.1099/mic.0.28294-0
van Belkum M.J., Stiles M.E.
"Characterization of the theta-type plasmid pCD3.4 from Carnobacterium divergens, and modulation of its host range by RepA mutation.", Microbiology 152:171-178(2006).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene311 | dvnA | divergicin A precursor bacteriocin | 40..267 |
| BACGene312 | dviA | divergicin A immunity protein bacteriocin immunity protein | 268..438 |
| BACGene313 | repA | RepA replication protein | 1486..2202 |
| BACGene314 | repA | hypothetical protein Orf-1 | 2328..2885 |
| BACGene315 | repA | hypothetical protein Orf-2 | 3132..3416 |
Protein sequence
| ........10 ........20 ........30 ........40 ........50 | | | | | AAPKITQKQK NCVNGQLGGM LAGALGGPGG VVLGGIGGAI AGGCFN |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1↔46 | 46 | Potential. Feature identifier = PRO_5000140377. |
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 6 | 13.04 % |
| C | 2 | 4.35 % |
| D | 0 | 0.00 % |
| E | 0 | 0.00 % |
| F | 1 | 2.17 % |
| G | 14 | 30.43 % |
| H | 0 | 0.00 % |
| I | 3 | 6.52 % |
| K | 3 | 6.52 % |
| L | 4 | 8.70 % |
| M | 1 | 2.17 % |
| N | 3 | 6.52 % |
| P | 2 | 4.35 % |
| Q | 3 | 6.52 % |
| R | 0 | 0.00 % |
| S | 0 | 0.00 % |
| T | 1 | 2.17 % |
| V | 3 | 6.52 % |
| W | 0 | 0.00 % |
| Y | 0 | 0.00 % |
Hydrophobicity
Composition
| Formula | C182
H305
N55
O54
S3 |
| Absent amino acids | DEHRSWY |
| Common amino acids | G |
| Mass (Da) | 4242.77 |
| Net charge | +3 |
| Isoelectric point | 9.67 |
| Basic residues | 3 |
| Acidic residues | 0 |
| Hydrophobic residues | 17 |
| Polar residues | 20 |
| Aliphatic residues | 10 |
| Tiny residues | 20 |
| Boman Index | 22.71 |
| Hydropathy Index | 0.43 |
| Aliphatic Index | 91.3 |
| Instability Index | 20.66 (stable) |
| Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 125 M-1 cm-1 |
| Absorbance 280nm | 2.78 |