Piscicolin 126

Accession: BAC081

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Bacteriocin: piscicolin 126

Accession: BAC081
Classification
Class: class IIA/YGNGV
Genetics
Gene: pisA
Producer and target organisms

Producer Organism: Carnobacterium piscicola [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesCarnobacteriaceaeCarnobacterium

Target organismsUnknown error type: [8] Uninitialized string offset: -1
Gram-positive bacteria: especially the food-borne pathogen Listeria monocytogenes - Carnobacterium - Enterococcus - Lactobacillus - Leuconostoc -

No effect on the growth of a number of yeasts & Gram-negative bacteria.

Description
Mode of action:
RANGE=19-62; NOTE=Ref.2.
Uniprot and PDB links

UniProt Entry: P80569 Q934J2

PDB EntryUnknown

[Ref. 1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=JG126
Gibbs G.M., Fitzgerald A., Selleck M.L., Harmark K., Hillier A.J., Davidson B.E.
"Characterization of the genes involved in the production of piscicolin 126, a bacteriocin from Carnobacterium piscicola JG126.", Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
[Ref. 2] | View abstract | Export citation
PROTEIN SEQUENCE OF 19-62, AND MASS SPECTROMETRY, STRAIN=JG126
MEDLINE=96316406;PubMed=8702282;
Jack R.W., Wan J., Gordon J., Harmark K., Davidson B.E., Hillier A.J., Wettenhall R.E.H., Hickey M.W., Coventry J.M.
"Characterization of the chemical and antimicrobial properties of piscicolin 126, a bacteriocin produced by Carnobacterium piscicola JG126.", Appl. Environ. Microbiol. 62:2897-2903(1996).
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Gene structure
genome of piscicolin 126

Gene idNameDescriptionLocation
BACGene290pisIputative piscicolin 126 immunity protein PisIcomplement(1275..1571)
BACGene291pisApiscicolin 126 protein PisA precursor cleaved after the double glycine upon translocation to yield the mature proteincomplement(1813..2001)
BACGene292pisNpiscicolin 126 induction factor PisN precursor cleaved after the double glycine upon translocation to yield the mature protein2231..2374
BACGene293pisKputative histidine kinase PisK2420..3706
BACGene294pisRputative response regulator PisR3720..4466
BACGene295pisTputative ABC transporter PisT4496..6646
BACGene296pisEputative accessory protein PisE6664..7644
pisIpisApisNpisKpisRpisTpisE
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 KYYGNGVSCN KNGCTVDWSK AIGIIGNNAA ANLTTGGAAG WNKG
Wheel representation
wheel representation of piscicolin 126
Protein sequence annotations
Features of piscicolin 126


FeaturePosition(s)LengthDescription
CHAIN1↔4444
Bacteriocin piscicolin-126.
Feature identifier = PRO_0000002739.
DISULFID9↔146By similarity.
Composition
Amino acidCountPercent
A613.64 %
C24.55 %
D12.27 %
E00.00 %
F00.00 %
G920.45 %
H00.00 %
I36.82 %
K49.09 %
L12.27 %
M00.00 %
N715.91 %
P00.00 %
Q00.00 %
R00.00 %
S24.55 %
T36.82 %
V24.55 %
W24.55 %
Y24.55 %
Hydrophobicity

Composition
Formula C190 H295 N57 O61 S2
Absent amino acids EFHMPQR
Common amino acids G
Mass (Da) 4436.66
Net charge +3
Isoelectric point 9.33
Basic residues 4
Acidic residues 1
Hydrophobic residues 14
Polar residues 25
Aliphatic residues 6
Tiny residues 17
Boman Index -37.89
Hydropathy Index -0.31
Aliphatic Index 62.27
Instability Index 22.82 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 328.02