Bacteriocin: Leucocin-B (Leucocin B-Ta11a)
Accession: BAC059
Classification
Class: class IIA/YGNGV
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Leuconostoc carnosum [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesLeuconostoc
Target organismsLactic bacteria - Listeria monocytogenes
Description
Mode of action:
heat stable bacteriocin.
heat stable bacteriocin.
Uniprot and PDB links
UniProt Entry: Q53446
PDB EntryUnknown
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=Ta11a
MEDLINE=95038272;PubMed=7765496;
Felix J.V., Papathanasopoulos M.A., Smith A.A., von Holy A., Hastings J.W.
"Characterization of leucocin B-Ta11a: a bacteriocin from Leuconostoc carnosum Ta11a isolated from meat.", Curr. Microbiol. 29:207-212(1994).
MEDLINE=95038272;PubMed=7765496;
Felix J.V., Papathanasopoulos M.A., Smith A.A., von Holy A., Hastings J.W.
"Characterization of leucocin B-Ta11a: a bacteriocin from Leuconostoc carnosum Ta11a isolated from meat.", Curr. Microbiol. 29:207-212(1994).
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Gene structure
| Gene id | Name | Description | Location |
| BACGene218 | leucocin B-Ta11a bacteriocin; precursor | 203..388 | |
| BACGene219 | putative immunity protein similar to leucocin A-UAL 187 | 408..749 |
Protein sequence
| ........10 ........20 ........30 ........40 | | | | KYYGNGVHCT KSGCSVNWGE AFSAGVHRLA NGGNGFW |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1↔37 | 37 | Bacteriocin leucocin-B. Feature identifier = PRO_0000002741. |
| DISULFID | 9↔14 | 6 | By similarity. |
Composition
| Amino acid | Count | Percent |
|---|---|---|
| A | 3 | 8.11 % |
| C | 2 | 5.41 % |
| D | 0 | 0.00 % |
| E | 1 | 2.70 % |
| F | 2 | 5.41 % |
| G | 8 | 21.62 % |
| H | 2 | 5.41 % |
| I | 0 | 0.00 % |
| K | 2 | 5.41 % |
| L | 1 | 2.70 % |
| M | 0 | 0.00 % |
| N | 4 | 10.81 % |
| P | 0 | 0.00 % |
| Q | 0 | 0.00 % |
| R | 1 | 2.70 % |
| S | 3 | 8.11 % |
| T | 1 | 2.70 % |
| V | 3 | 8.11 % |
| W | 2 | 5.41 % |
| Y | 2 | 5.41 % |
Hydrophobicity
Composition
| Formula | C174
H248
N52
O50
S2 |
| Absent amino acids | DIMPQ |
| Common amino acids | G |
| Mass (Da) | 3950.93 |
| Net charge | +4 |
| Isoelectric point | 8.77 |
| Basic residues | 5 |
| Acidic residues | 1 |
| Hydrophobic residues | 11 |
| Polar residues | 20 |
| Aliphatic residues | 4 |
| Tiny residues | 14 |
| Boman Index | -38.59 |
| Hydropathy Index | -0.39 |
| Aliphatic Index | 42.16 |
| Instability Index | -1.5 (stable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 14105 M-1 cm-1 |
| Absorbance 280nm | 391.81 |