Halocin-S8

Accession: BAC055

Bacteriocin: Halocin-S8

Classification

Class: ~~Unclassified~~

Genetics

Gene: halS8

Producer and target organisms

Producer Organism: Haloarchaeon S8a [Gram-]

Description

Mode of action:
boiled, subjected to organic solvents, and stored at 4 degrees Celsius for extended periods without losing activity.

Related Entries

Uniprot and PDB links

UniProt Entry: Q9HHA8

PDB Entry~~Unknown~~

NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 231-266.
MEDLINE=20398181;PubMed=10940040;DOI=10.1128/JB.182.17.4951-4958.2000
Price L.B., Shand R.F.
"Halocin S8: a 36-amino-acid microhalocin from the haloarchaeal strain S8a.", J. Bacteriol. 182:4951-4958(2000).

Gene structure

Gene id	Name	Description	Location
BACGene196	halS8	HalS8 precursor halocin S8; preproprotein	1095..2030

Protein sequence

........10 ........20 ........30 ........40
| | | |
SDCNINSNTA ADVILCFNQV GSCALCSPTL VGGPVP

Wheel representation

Protein sequence annotations

Feature	Position(s)	Length	Description
PEPTIDE	1↔36	36	Halocin-S8. Feature identifier = PRO_0000013171.
PROPEP	37↔81	45	/FTId=PRO_0000013172.

Composition

Hydrophobicity

Composition

Formula	C₁₅₀ H₂₄₃ N₄₁ O₅₂ S₄
Absent amino acids	EHKMRWY
Common amino acids	CNSV
Mass (Da)	3599.68
Net charge	-2
Isoelectric point	3.49
Basic residues	0
Acidic residues	2
Hydrophobic residues	13
Polar residues	17
Aliphatic residues	9
Tiny residues	10
Boman Index	-11.17
Hydropathy Index	0.56
Aliphatic Index	94.72
Instability Index	49.04 (unstable)
Half Life	Mammalian : 1.9 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	250 M^-1 cm^-1
Absorbance 280nm	7.14