Plantaricin K

Accession: BAC044

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Bacteriocin: plantaricin K

Accession: BAC044

Classification

Class: ~~Unclassified~~

Genetics

Gene: plnK

Producer and target organisms

Producer Organism: Lactobacillus plantarum [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsPediococcus pentosaceus - Lactobacillus plantarum - Lactobacillus casei - Lactobacillus sakei - Lactobacillus viridescens - Pediococcus pentosaceus - Carnobacterium piscicola - Lactobacillus plantarum - Lactobacillus sakei - Pediococcus acidilactici - Lactobacillus curvatus

Uniprot and PDB links

UniProt Entry: P71460

PDB Entry2KEG resolved by NMR. Structure in dpc micelles 2KEH resolved by NMR. (TFE)

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=94161498;PubMed=8117074;
Diep B.D., Havarstein L.S., Nissen-Meyer J., Nes F.I.
"The gene encoding plantaricin A, a bacteriocin from Lactobacillus plantarum C11, is located on the same transcription unit as an agr- like regulatory system.", Appl. Environ. Microbiol. 60:160-166(1994).

[Ref. 2] | View abstract | Export citation

NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=C11
MEDLINE=96345611;PubMed=8755874;
Diep D.B., Havarstein L.S., Nes I.F.
"Characterization of the locus responsible for the bacteriocin production in Lactobacillus plantarum C11.", J. Bacteriol. 178:4472-4483(1996).

[Ref. 3] | View abstract | Export citation

NUCLEOTIDE SEQUENCE, STRAIN=C11
MEDLINE=96414465;PubMed=8817486;
Diep D.B., Haavarstein S.L., Nes I.F.
"A bacteriocin-like peptide induces bacteriocin synthesis in Lactobacillus plantarum C11.", Mol. Microbiol. 18:631-639(1995).

[Ref. 4] | View abstract | Export citation

NUCLEOTIDE SEQUENCE, STRAIN=NC8
PubMed=14973042;DOI=10.1128/JB.186.5.1556-1564.2004
Maldonado A., Jimenez-Diaz R., Ruiz-Barba J.L.
"Induction of plantaricin production in Lactobacillus plantarum NC8 after coculture with specific gram-positive bacteria is mediated by an autoinduction mechanism.", J. Bacteriol. 186:1556-1564(2004).

Protein sequence

........10 ........20 ........30 ........40
| | | |
RRSRKNGIGY AIGYAFGAVE RAVLGGSRDY NK

Wheel representation

3D Structure

View PDB entry: 2KEG

Protein sequence annotations

Feature	Position(s)	Length	Description
CHAIN	1↔32	32	bacteriocin peptide K. Feature identifier = PRO_5000146710.
CHAIN	1↔32	32	bacteriocin peptide PlnK. Feature identifier = PRO_5000063929.

Composition

Amino acid	Count	Percent
A	4	12.50 %
C	0	0.00 %
D	1	3.13 %
E	1	3.13 %
F	1	3.13 %
G	6	18.75 %
H	0	0.00 %
I	2	6.25 %
K	2	6.25 %
L	1	3.13 %
M	0	0.00 %
N	2	6.25 %
P	0	0.00 %
Q	0	0.00 %
R	5	15.63 %
S	2	6.25 %
T	0	0.00 %
V	2	6.25 %
W	0	0.00 %
Y	3	9.38 %

Hydrophobicity

Composition

Formula	C₁₅₃ H₂₄₅ N₅₁ O₄₄
Absent amino acids	CHMPQTW
Common amino acids	G
Mass (Da)	3521.46
Net charge	+5
Isoelectric point	10.98
Basic residues	7
Acidic residues	2
Hydrophobic residues	10
Polar residues	13
Aliphatic residues	5
Tiny residues	12
Boman Index	-83.03
Hydropathy Index	-0.66
Aliphatic Index	67.19
Instability Index	64.1 (unstable)
Half Life	Mammalian : 1 hour Yeast : 2 min E. coli : 2 min
Extinction Coefficient	4470 M^-1 cm^-1
Absorbance 280nm	144.19