Acidocin 8912

Accession: BAC029

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Bacteriocin: acidocin 8912

Accession: BAC029
Classification
Class: Unclassified
Genetics
Gene: acdT
Producer and target organisms

Producer Organism: Lactobacillus acidophilus [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLactobacillaceaeLactobacillus

Target organismsUnavailable data

Description
Mode of action:
Has a bactericidal effect on sensitive cells but not a bacteriolytic effect.
Uniprot and PDB links

UniProt Entry: Q48501 Q9R5H2

PDB EntryUnknown

[Ref. 1] | View abstract | Export citation
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
MEDLINE=96140009;PubMed=8554765;
Kanatani K., Tahara T., Oshimura M., Sano K., Umezawa C.
"Cloning and nucleotide sequence of the gene for acidocin 8912, a bacteriocin from Lactobacillus acidophilus TK8912.", Lett. Appl. Microbiol. 21:384-386(1995).
[Ref. 2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], STRAIN=TK8912
Nakachi I.
"", Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[Ref. 3] | View abstract | Export citation
PROTEIN SEQUENCE OF 21-44, STRAIN=TK8912
MEDLINE=93005074;PubMed=1368836;
Tahara T., Kanatani K., Yoshida K., Miura H., Sakamoto M., Oshimura M.
"Purification and some properties of acidocin 8912, a novel bacteriocin produced by Lactobacillus acidophilus TK8912.", Biosci. Biotechnol. Biochem. 56:1212-1215(1992).
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Gene structure
genome of acidocin 8912

Gene idNameDescriptionLocation
BACGene91hypothetical proteincomplement(297..722)
BACGene92RepA2replication protein A2113..2292
BACGene93RepA1replication protein A2934..3782
BACGene94RepBreplication protein Bcomplement(3968..4477)
BACGene95acd Macidocin M Start codon is not identified.5367..5618
BACGene96acd Mhypothetical protein5618..5929
BACGene97acd MABC transporter6385..8478
BACGene98acd Maccessory protein8471..9865
BACGene99acd Tacidocin 891210024..10164
BACGene100acd Thypothetical protein10496..10873
BACGene101acd Ttransposasecomplement(11042..11428)
BACGene102acd Ttransposasecomplement(11507..11725)
BACGene103acd Thypothetical proteincomplement(12021..12413)
BACGene104acd Thypothetical protein12703..13467
BACGene105acd Thypothetical protein13564..13905
RepA2RepA1RepBacd Macd Macd Macd Macd Tacd Tacd Tacd Tacd Tacd Tacd T
Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 KTHYPTNAWK SLWKGFWESL RYTDGF
Wheel representation
wheel representation of acidocin 8912
Protein sequence annotations
Features of acidocin 8912


FeaturePosition(s)LengthDescription
PEPTIDE1↔2626
Bacteriocin acidocin 8912.
Feature identifier = PRO_0000002763.
CONFLICT13W -> R (in Ref. 3; AA sequence).
Composition
Amino acidCountPercent
A13.85 %
C00.00 %
D13.85 %
E13.85 %
F27.69 %
G27.69 %
H13.85 %
I00.00 %
K311.54 %
L27.69 %
M00.00 %
N13.85 %
P13.85 %
Q00.00 %
R13.85 %
S27.69 %
T311.54 %
V00.00 %
W311.54 %
Y27.69 %
Hydrophobicity

Composition
Formula C154 H212 N38 O39
Absent amino acids CIMQV
Common amino acids KTW
Mass (Da) 3238.01
Net charge +3
Isoelectric point 9.87
Basic residues 5
Acidic residues 2
Hydrophobic residues 8
Polar residues 10
Aliphatic residues 2
Tiny residues 5
Boman Index -46.71
Hydropathy Index -1.01
Aliphatic Index 33.85
Instability Index 39.97 (stable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 19480 M-1 cm-1
Absorbance 280nm 779.2