Bacteriocin: Enterocin K1
Accession: BAC230
Classification
Class: Leaderless
Genetics
Gene: OKA_05812
Producer and target organisms
Producer Organism: Enterococcus faecium EnGen0026 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Bacilli
Lactobacillales
Enterococcaceae
Enterococcus
Target organismsStaphylococcus aureus (MIC >5500 nM) - Staphylococcus epidermidis (MIC >5500 nM) - Enterococcus faecalis (MIC= 2700- >5500 nM) - Enterococcus faecium (MIC= 10-85 nM) - Enterococcus hirae (MIC= 45 nM) - Lactococcus garvieae (MIC= 340-1370 nM) - Lactobacillus spp. (MIC= 5500- >5500 nM) - Lactococcus lactis 1L1403 (MIC= 170 nM) - Lactococcus lactic (MIC >5500 nM) - Bacillus cereus (MIC= 2750- >5500 nM) - Listeria monocytogenes (MIC >5500 nM)
Description
NULL
Uniprot and PDB links
UniProt Entry: L2P7L3
PDB Entry5L82 resolved by NMR
STRUCTURE AND FUNCTION
PubMed=28515717;DOI=10.3389/fmicb.2017.00774
Ovchinnikov K.V., Kristiansen P.E., Straume D., Jensen M.S., Aleksandrzak-Piekarczyk T., Nes I.F., Diep D.B.
"The Leaderless Bacteriocin Enterocin K1 Is Highly Potent against Enterococcus faecium: A Study on Structure, Target Spectrum and Receptor.", Front Microbiol 2017, 8 ():774.
PubMed=28515717;DOI=10.3389/fmicb.2017.00774
Ovchinnikov K.V., Kristiansen P.E., Straume D., Jensen M.S., Aleksandrzak-Piekarczyk T., Nes I.F., Diep D.B.
"The Leaderless Bacteriocin Enterocin K1 Is Highly Potent against Enterococcus faecium: A Study on Structure, Target Spectrum and Receptor.", Front Microbiol 2017, 8 ():774.
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Protein sequence
........10 ........20 ........30 ........40 | | | | MKFKFNPTGT IVKKLTQYEI AWFKNKHGYY PWEIPRC |
Wheel representation
3D Structure
Protein sequence annotations
Feature | Position(s) | Length | Description |
CHAIN | 1↔37 | 37 | Bacteriocin Enterocin K1.
Feature identifier = |
HELIX | 8↔24 | 17 |
Composition
Hydrophobicity
Composition
Formula | C
H
N
O1
|
Absent amino acids | DS |
Common amino acids | K |
Mass (Da) | 4564.88 |
Net charge | +6 |
Isoelectric point | 10.24 |
Basic residues | 8 |
Acidic residues | 2 |
Hydrophobic residues | 11 |
Polar residues | 11 |
Aliphatic residues | 5 |
Tiny residues | 3 |
Boman Index | -48.81 |
Hydropathy Index | -0.7 |
Aliphatic Index | 52.7 |
Instability Index | -0.45 (stable) |
Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 15470 M-1 cm-1 |
Absorbance 280nm | 429.72 |
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