Bacteriocin: Enterocin K1

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Bacteriocin: Enterocin K1

Accession: BAC230

Classification
Class: Leaderless
Genetics
Gene: OKA_05812
Producer and target organisms

Producer Organism: Enterococcus faecium EnGen0026 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus

Target organismsStaphylococcus aureus (MIC >5500 nM) - Staphylococcus epidermidis (MIC >5500 nM) - Enterococcus faecalis (MIC= 2700- >5500 nM) - Enterococcus faecium (MIC= 10-85 nM) - Enterococcus hirae (MIC= 45 nM) - Lactococcus garvieae (MIC= 340-1370 nM) - Lactobacillus spp. (MIC= 5500- >5500 nM) - Lactococcus lactis 1L1403 (MIC= 170 nM) - Lactococcus lactic (MIC >5500 nM) - Bacillus cereus (MIC= 2750- >5500 nM) - Listeria monocytogenes (MIC >5500 nM)

Description
NULL
STRUCTURE AND FUNCTION
PubMed=28515717;DOI=10.3389/fmicb.2017.00774
Ovchinnikov K.V., Kristiansen P.E., Straume D., Jensen M.S., Aleksandrzak-Piekarczyk T., Nes I.F., Diep D.B.
"The Leaderless Bacteriocin Enterocin K1 Is Highly Potent against Enterococcus faecium: A Study on Structure, Target Spectrum and Receptor.", Front Microbiol 2017, 8 ():774.
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Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 MKFKFNPTGT IVKKLTQYEI AWFKNKHGYY PWEIPRC

Wheel representation
wheel representation of Enterocin K1
3D Structure
Protein sequence annotations
Features of Enterocin K1


FeaturePosition(s)LengthDescription
CHAIN1↔3737
Bacteriocin Enterocin K1.
Feature identifier =
HELIX8↔2417
Composition
Hydrophobicity

Composition
Formula C H N Unknown error type: [8] Undefined offset: 1
O1
Absent amino acids DS
Common amino acids K
Mass (Da) 4564.88
Net charge +6
Isoelectric point 10.24
Basic residues 8
Acidic residues 2
Hydrophobic residues 11
Polar residues 11
Aliphatic residues 5
Tiny residues 3
Boman Index -48.81
Hydropathy Index -0.7
Aliphatic Index 52.7
Instability Index -0.45 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 15470 M-1 cm-1
Absorbance 280nm 429.72

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