Bacteriocin: BacCH91

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Bacteriocin: BacCH91

Accession: BAC226

Gene: BacCH91
Producer and target organisms

Producer Organism: Staphylococcus aureus CH-91 DSM 26258 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesStaphylococcus

Target organismsMicrococcus luteus (MIC=2.5 nM) - staphylococcus staphylococcus (MIC range 1.3-6.0 μM) - Lactococcus lactis (MIC=100 μM) -

Note: ineffective against tested Gram-negative strains at maximal concentration (100 µM)

It is a thermostable peptide that is highly resistant to cleavage by both prokaryotic and eukaryotic peptidases.

The encoding gene (BacCH91) occurred in two allelic variants distinguishable in the restriction fragment length polymorphism assay. Variant I, identified in S. aureus CH-91, dominated in S. aureus strains of poultry origin, although strains with variant II were also identified in this group. S. aureus strains of human origin were characterized exclusively by variant II.
Uniprot and PDB links

UniProt Entry: I6XG59

PDB EntryUnknown

Wladyka B., Wielebska K., Wloka M., Bochenska O., Dubin G., Dubin A., Mak P.
"Isolation, biochemical characterization, and cloning of a bacteriocin from the poultry-associated Staphylococcus aureus strain CH-91.", Appl Microbiol Biotechnol 2013, 97 (16):7229-39.
End Note
Reference Manager
Protein sequence
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Wheel representation
wheel representation of BacCH91

Formula C0 H0 N0 O0 S0
Absent amino acids ADEHLMQRVWY
Common amino acids GC
Mass (Da) 2
Net charge +1
Isoelectric point 7.92
Basic residues 1
Acidic residues 0
Hydrophobic residues 5
Polar residues 15
Aliphatic residues 2
Tiny residues 7
Boman Index -2.44
Hydropathy Index 0.559
Aliphatic Index 35.45
Instability Index 16.65 (stable)
Half Life Mammalian : 20 hour
Yeast : 30 min
E. coli : >10 hour
Extinction Coefficient 250 M-1 cm-1
Absorbance 280nm 11.9

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