Bacteriocin: NAI-107

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Bacteriocin: NAI-107

Accession: BAC222

Classification
Class: Lantibiotic
Genetics
Gene: mlbA
Producer and target organisms
Uniprot and PDB links

UniProt Entry: P85065

PDB Entry2MH5 resolved by NMR

NUCLEOTIDE SEQUENCE, STRAIN=ATCC PTA-5024.
PubMed=24459268;
Sosio M., Gallo G., Pozzi R., Serina S., Monciardini P., Bera A., Stegmann E., Weber T.
"Draft Genome Sequence of the Microbispora sp. Strain ATCC-PTA-5024, Producing the Lantibiotic NAI-107.", Genome Announc. 2:e01198-13(2014).
PROTEIN SEQUENCE, FUNCTION, POST-TRANSLATIONAL MODIFICATIONS, AND MASS SPECTROMETRY.
Lazzarini A., Gastaldo L., Candiani G., Ciciliato I., Losi D., Marinelli F., Selva E., Parenti F.
"Antibiotic 107891, its factors A1 and A2, pharmaceutically acceptable salts and compositions, and use thereof.", Patent number WO2005014628, 17-FEB-2005.
PROTEIN STRUCTURE AND MECHANISM OF ACTION
PubMed=24627484;DOI=10.1074/jbc.M113.537449
Munch D., Muller A., Schneider T., Kohl B., Wenzel M., Bandow J.E., Maffioli S., Sosio M., Donadio S., Wimmer R., Sahl H.
"The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.", J Biol Chem 2014, 289 (17):12063-76.
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Protein sequence
 ........10 ........20 ........30 
          |          |          | 
 VTSWSLCTPG CTSPGGGSNC SFCC

Wheel representation
wheel representation of NAI-107
3D Structure
Protein sequence annotations
Features of NAI-107

TWSP
FeaturePosition(s)LengthDescription
PEPTIDE1↔2424
Lantibiotic 107891.
Feature identifier = PRO_0000271410.
Modified residue2(E)-2,3-didehydrobutyrine.
Modified residue46'-chlorotryptophan.
Modified residue52,3-didehydroalanine (Ser).
Modified residue143,4-dihydroxyproline; in form A1.
Modified residue144-hydroxyproline; in form A2.
Cross-link3↔75Lanthionine (Ser-Cys).
Cross-link8↔114Beta-methyllanthionine (Thr-Cys).
Cross-link13↔208Lanthionine (Ser-Cys).
Cross-link18↔236Lanthionine (Ser-Cys).
Cross-link21↔244S-(2-aminovinyl)-D-cysteine (Ser-Cys).
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids ADEHIKMQRY
Common amino acids SC
Mass (Da) 2
Net charge 0
Isoelectric point 5.66
Basic residues 0
Acidic residues 0
Hydrophobic residues 4
Polar residues 18
Aliphatic residues 2
Tiny residues 9
Boman Index -6.92
Hydropathy Index 0.333
Aliphatic Index 28.33
Instability Index 60.6 (unstable)
Half Life Mammalian : 100 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 5750 M-1 cm-1
Absorbance 280nm 250

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