Bacteriocin: Paenicidin A

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Bacteriocin: Paenicidin A

Accession: BAC215

Class: Lantibiotic
Gene: paeA
Producer and target organisms

Producer Organism: Paenibacillus polymyxa NRRL B-30509 (Bacillus polymyxa) [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesPaenibacillaceaePaenibacillus

Target organismsUnavailable data

Uniprot and PDB links

UniProt Entry: K7TS19

PDB EntryUnknown

STRUCTURE BY NMR, STRAIN=Paenibacillus polymyxa NRRL B-30509.
Lohans C.T., Huang Z., van Belkum M.J., Giroud M., Sit C.S., Steels E.M., Zheng J., Whittal R.M., McMullen L.M., Vederas J.C.
"Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy.", J Am Chem Soc. (2012).
End Note
Reference Manager
Gene structure
genome of Paenicidin A

Gene idNameDescriptionLocation
BACGene957paeAPaeA paenicidin A structural gene1..177
BACGene958paeFPaeF ABC transporter ATP binding protein346..1074
BACGene959paeEPaeE ABC transporter membrane-bound subunit1071..1871
BACGene960paeGPaeG ABC transporter membrane-bound subunit1884..2651
BACGene961paeBPaeB lantibiotic dehydratase2679..5855
BACGene962paeTPaeT lantibiotic ABC transporter5852..7729
BACGene963paeCPaeC lantibiotic cyclase7731..9113
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 

Wheel representation
wheel representation of Paenicidin A

Formula C0 H0 N0 O0 S0
Absent amino acids DHMPQWY
Common amino acids SC
Mass (Da) 3376.5
Net charge +1
Isoelectric point 7.73
Basic residues 2
Acidic residues 1
Hydrophobic residues 11
Polar residues 22
Aliphatic residues 7
Tiny residues 14
Boman Index -16.96
Hydropathy Index 0.675
Aliphatic Index 73.06
Instability Index 20.63 (stable)
Half Life Mammalian : 100 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 375 M-1 cm-1
Absorbance 280nm 10.71

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