Bacteriocin: Paenicidin A
Accession: BAC215
Classification
Class: Lantibiotic
Genetics
Gene: paeA
Producer and target organisms
Producer Organism: Paenibacillus polymyxa NRRL B-30509 (Bacillus polymyxa) [Gram-positive]
Taxonomy: BacteriaFirmicutes
Bacillales
Paenibacillaceae
Paenibacillus
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: K7TS19
PDB EntryUnknown
STRUCTURE BY NMR, STRAIN=Paenibacillus polymyxa NRRL B-30509.
PubMed=23167271;DOI=10.1021/ja3089229
Lohans C.T., Huang Z., van Belkum M.J., Giroud M., Sit C.S., Steels E.M., Zheng J., Whittal R.M., McMullen L.M., Vederas J.C.
"Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy.", J Am Chem Soc. (2012).
PubMed=23167271;DOI=10.1021/ja3089229
Lohans C.T., Huang Z., van Belkum M.J., Giroud M., Sit C.S., Steels E.M., Zheng J., Whittal R.M., McMullen L.M., Vederas J.C.
"Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy.", J Am Chem Soc. (2012).
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Gene structure
Gene id | Name | Description | Location |
BACGene957 | paeA | PaeA paenicidin A structural gene | 1..177 |
BACGene958 | paeF | PaeF ABC transporter ATP binding protein | 346..1074 |
BACGene959 | paeE | PaeE ABC transporter membrane-bound subunit | 1071..1871 |
BACGene960 | paeG | PaeG ABC transporter membrane-bound subunit | 1884..2651 |
BACGene961 | paeB | PaeB lantibiotic dehydratase | 2679..5855 |
BACGene962 | paeT | PaeT lantibiotic ABC transporter | 5852..7729 |
BACGene963 | paeC | PaeC lantibiotic cyclase | 7731..9113 |
Protein sequence
........10 ........20 ........30 ........40 | | | | VLSIVACSSG CGSGKTAASC VETCGNRCFT NVGSLC |
Wheel representation
Composition
Hydrophobicity
Composition
Formula | C0
H0
N0
O0
S0 |
Absent amino acids | DHMPQWY |
Common amino acids | SC |
Mass (Da) | 3376.5 |
Net charge | +1 |
Isoelectric point | 7.73 |
Basic residues | 2 |
Acidic residues | 1 |
Hydrophobic residues | 11 |
Polar residues | 22 |
Aliphatic residues | 7 |
Tiny residues | 14 |
Boman Index | -16.96 |
Hydropathy Index | 0.675 |
Aliphatic Index | 73.06 |
Instability Index | 20.63 (stable) |
Half Life |
Mammalian : 100 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 375 M-1 cm-1 |
Absorbance 280nm | 10.71 |
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