Bacteriocin: Enterocin W beta
Accession: BAC214
Producer Organism: Enterococcus faecalis (Streptococcus faecalis) [Gram-]
Taxonomy: Bacteria
FirmicutesLactobacillalesEnterococcaceaeEnterococcus
Target organismsBacillus coagulans JCM 2257 (MIC=9.7µM) - Bacillus circulans JCM 2504 (MIC=77.9µM) - Listeria innocua ATCC 33090 (MIC=311.6µM) - Pediococcus pentosaceus JCM 5885 (MIC=77.9µM) - Enterococcus faecalis JCM 5803 (MIC=19.7µM) - Lactococcus lactis subsp. lactis JCM 7638 (MIC=4.8µM) - Lactococcus lactis subsp. lactis ATCC 19435 (MIC=36.7µM) - Lactobacillus sakeisubsp. sakei JCM 1157 (MIC=77µM) -
NOTE: not active against Bacillus subtilis JCM 146 NOTE: not active against Bacillus subtilis JCM 1465 - Kocuria rhizophila NBRC 12708 (>3.2 μM)}
UniProt Entry: H3JST0
PDB EntryUnknown
PubMed=22138996;DOI=10.1128/AEM.06497-11
Sawa N., Wilaipun P., Kinoshita S., Zendo T., Leelawatcharamas V., Nakayama J., Sonomoto K.
"Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1.", Appl. Environ. Microbiol. 78:900-903(2012).
| Gene id | Name | Description | Location |
| BACGene955 | enwA | enterocin W alfa enw of two-peptide lantibiotic | 55..237 |
| BACGene956 | enwB | enterocin W beta enw of two-peptide lantibiotic | 256..441 |
| ........10 ........20 ........30 | | | VTTSIPCTVM VSAAVCPTLV CSNKCGGRG |
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | DEFHQWY |
| Common amino acids | V |
| Mass (Da) | 2 |
| Net charge | +2 |
| Isoelectric point | 8.34 |
| Basic residues | 2 |
| Acidic residues | 0 |
| Hydrophobic residues | 9 |
| Polar residues | 15 |
| Aliphatic residues | 7 |
| Tiny residues | 8 |
| Boman Index | -3.64 |
| Hydropathy Index | 0.803 |
| Aliphatic Index | 83.79 |
| Instability Index | 30.51 (stable) |
| Half Life |
Mammalian : 100 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 250 M-1 cm-1 |
| Absorbance 280nm | 8.93 |
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