Bacteriocin: Enterocin W alfa

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Bacteriocin: Enterocin W alfa

Accession: BAC213

Classification
Class: Class IIb
Genetics
Gene: enwA
Producer and target organisms

Producer Organism: Enterococcus faecalis (Streptococcus faecalis) [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsBacillus coagulans JCM 2257 (MIC=7.95µM) - Bacillus circulans JCM 2504 (MIC=31.8µM) - Listeria innocua ATCC 33090 (MIC=7.95µM) - Pediococcus pentosaceus JCM 5885 (MIC=31.6µM) - Enterococcus faecalis JCM 5803 (MIC=15.9µM) - Lactococcus lactis subsp. lactis JCM 7638 (MIC=33.8µM) - Lactococcus lactis subsp. lactis ATCC 19435 (MIC=3.97µM) - Lactobacillus sakeisubsp. sakei JCM 1157 (MIC=7.95µM) -

NOTE: not active against Bacillus subtilis JCM 146 NOTE: not active against Bacillus subtilis JCM 1465 - Kocuria rhizophila NBRC 12708 (>3.2 μM)}

NUCLEOTIDE SEQUENCE, STRAIN=NKR-4-1.
PubMed=22138996;DOI=10.1128/AEM.06497-11
Sawa N., Wilaipun P., Kinoshita S., Zendo T., Leelawatcharamas V., Nakayama J., Sonomoto K.
"Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1.", Appl. Environ. Microbiol. 78:900-903(2012).
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Gene structure
genome of Enterocin W alfa

Gene idNameDescriptionLocation
BACGene953enwAenterocin W alfa enw of two-peptide lantibiotic55..237
BACGene954enwBenterocin W beta enw of two-peptide lantibiotic256..441
enwAenwB
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 KCPWWNLSCH LGNDGKICTY SHECTAGCNA

Wheel representation
wheel representation of Enterocin W alfa
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids FMQRV
Common amino acids C
Mass (Da) 3
Net charge +2
Isoelectric point 7.24
Basic residues 4
Acidic residues 2
Hydrophobic residues 7
Polar residues 16
Aliphatic residues 3
Tiny residues 7
Boman Index -35.69
Hydropathy Index -0.413
Aliphatic Index 45.67
Instability Index 68.86 (unstable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 12740 M-1 cm-1
Absorbance 280nm 439.31

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