Bacteriocin: Enterocin W alfa
Accession: BAC213
Producer Organism: Enterococcus faecalis (Streptococcus faecalis) [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesEnterococcaceaeEnterococcus
Target organismsBacillus coagulans JCM 2257 (MIC=7.95µM) - Bacillus circulans JCM 2504 (MIC=31.8µM) - Listeria innocua ATCC 33090 (MIC=7.95µM) - Pediococcus pentosaceus JCM 5885 (MIC=31.6µM) - Enterococcus faecalis JCM 5803 (MIC=15.9µM) - Lactococcus lactis subsp. lactis JCM 7638 (MIC=33.8µM) - Lactococcus lactis subsp. lactis ATCC 19435 (MIC=3.97µM) - Lactobacillus sakeisubsp. sakei JCM 1157 (MIC=7.95µM) -
NOTE: not active against Bacillus subtilis JCM 146 NOTE: not active against Bacillus subtilis JCM 1465 - Kocuria rhizophila NBRC 12708 (>3.2 μM)}
UniProt Entry: H3JSS9
PDB EntryUnknown
PubMed=22138996;DOI=10.1128/AEM.06497-11
Sawa N., Wilaipun P., Kinoshita S., Zendo T., Leelawatcharamas V., Nakayama J., Sonomoto K.
"Isolation and Characterization of Enterocin W, a Novel Two-Peptide Lantibiotic Produced by Enterococcus faecalis NKR-4-1.", Appl. Environ. Microbiol. 78:900-903(2012).
| Gene id | Name | Description | Location |
| BACGene953 | enwA | enterocin W alfa enw of two-peptide lantibiotic | 55..237 |
| BACGene954 | enwB | enterocin W beta enw of two-peptide lantibiotic | 256..441 |
| ........10 ........20 ........30 ........40 | | | | KCPWWNLSCH LGNDGKICTY SHECTAGCNA |
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | FMQRV |
| Common amino acids | C |
| Mass (Da) | 3 |
| Net charge | +2 |
| Isoelectric point | 7.24 |
| Basic residues | 4 |
| Acidic residues | 2 |
| Hydrophobic residues | 7 |
| Polar residues | 16 |
| Aliphatic residues | 3 |
| Tiny residues | 7 |
| Boman Index | -35.69 |
| Hydropathy Index | -0.413 |
| Aliphatic Index | 45.67 |
| Instability Index | 68.86 (unstable) |
| Half Life |
Mammalian : 1.3 hour Yeast : 3 min E. coli : 2 min |
| Extinction Coefficient | 12740 M-1 cm-1 |
| Absorbance 280nm | 439.31 |
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