Bacteriocin: LCI

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Bacteriocin: LCI

Accession: BAC212

Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Bacillus subtilis A14 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesBacillaceaeBacillus

Target organismsXanthonionas campestris pv. oryzae G - Xanthonionas campestris pv. oryzae X4 - Xanthonionas campestris pv. oryzae X17 - Xanthonionas campestris pv. oryzae X61 - Pseudomonas solanacearum -

NOTE: not active against Erwinia carotovora subsp. carotovora - Escherichia coli

Description
FUNCTION: May bind DNA or mRNA.

SUBCELLULAR LOCATION: Secreted.

MISCELLANEOUS:
- Heat stable.
- Resistant to proteolysis by tryspin and pepsin, but susceptible to pronase E and proteinase K.
Uniprot and PDB links

UniProt Entry: P82243

PDB Entry2B9K resolved by NMR

PROTEIN SEQUENCE OF 1-27, FUNCTION, AND STABILITY, STRAIN=A014.
Liu J.-Y., Pan N.-S., Chen Z.-L.
"Characterization of an anti-rice bacterial blight polypeptide LCI.", Rice Genet. Newsl. 7:151-154(1990).
PROTEIN STRUCTURE, STRAIN=A014.
PubMed=21449609;DOI=10.1021/bi200123w
Xia, B.; Gong, W.; Lu, G.
"Solution Structure of LCI, a Novel Antimicrobial Peptide from Bacillus subtilis", Biochemistry, 50 (18): 36213627 (2011).
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Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 
 AIKLVQSPNG NFAASFVLDG TKWIFKSKYY DSSKGYWVGI YEVWDRK

Wheel representation
wheel representation of LCI
3D Structure
Protein sequence annotations
Features of LCI


FeaturePosition(s)LengthDescription
CHAIN1↔4747
Antimicrobial peptide LCI.
Feature identifier = PRO_0000064937.
STRAND3↔75
STRAND15↔184
STRAND21↔3010
TURN32↔343
STRAND35↔439
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids CHM
Common amino acids K
Mass (Da) 5
Net charge +3
Isoelectric point 9.85
Basic residues 7
Acidic residues 4
Hydrophobic residues 18
Polar residues 16
Aliphatic residues 9
Tiny residues 12
Boman Index -54.26
Hydropathy Index -0.351
Aliphatic Index 72.55
Instability Index 13.08 (stable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 22460 M-1 cm-1
Absorbance 280nm 488.26

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