Bacteriocin: Laterosporulin

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Bacteriocin: Laterosporulin

Accession: BAC211

Class: IId
Gene: laterosporulin
Producer and target organisms

Producer Organism: Brevibacillus sp. GI-9 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesPaenibacillaceaeBrevibacillus

Target organismsBacillus subtilis MTCC 121 (MIC=1.5µg/ml) - Staphylococcus aureus MTCC 1430 (MIC=1.5µg/ml) - Listeria monocytogenes MTCC 839 (MIC=22.5µg/ml) - Pseudomonas aeruginosa MTCC 1934 (MIC=15µg/ml) - Escherichia coli MTCC 1610 (MIC=7.5µg/ml) - Vibrio cholerae (MIC=15µg/ml) -

NOT active against: tested yeast or fungi

Physicochemical features:
- incubation of laterosporulin with proteolytic enzymes (pepsin, trypsin, chymotrypsin, proteinase K, pronase E) did not show any reduction in its antimicrobial activity.

- fully heat stable as it keeps its antimicrobial activity after exposure to 120C for 15 min.
Uniprot and PDB links

UniProt Entry: H1ZZ98

PDB Entry4OZK resolved by X-RAY

Singh P.K., Ashish C., Sharma V., Patil P.B., Korpole S.
"Identification, purification and characterization of laterosporulin, a novel bacteriocin produced by Brevibacillus sp. strain GI-9.", PLoS ONE 7:e31498-e31498(2012).
End Note
Reference Manager
Gene structure
genome of Laterosporulin

Gene idNameDescriptionLocation
BACGene948transcriptional regulator ORF135..727
BACGene949laterosporulinputative bacteriocin982..1134
BACGene950laterosporulinhypothetical protein ORF21223..1708
BACGene951laterosporulinABC transporter ORF31711..3561
BACGene952laterosporulinputative dehydrogenase ORF43566..4000
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
          |          |          |          |          | 

Wheel representation
wheel representation of Laterosporulin
3D Structure

Formula C0 H0 N0 O0 S0
Absent amino acids F
Common amino acids C
Mass (Da) 5
Net charge +2
Isoelectric point 6.73
Basic residues 6
Acidic residues 4
Hydrophobic residues 10
Polar residues 23
Aliphatic residues 5
Tiny residues 10
Boman Index -82.3
Hydropathy Index -0.49
Aliphatic Index 41.84
Instability Index 45.65 (unstable)
Half Life Mammalian : 4.4 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 17335 M-1 cm-1
Absorbance 280nm 361.15

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