Bacteriocin: Epidermicin NI01
Accession: BAC210
Producer Organism: Staphylococcus epidermidis 224 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Bacillales
Staphylococcus
Target organismsStaphylococcus epidermidis 1 (MIC=1µg/ml) - Staphylococcus epidermidis 2 (MIC=4µg/ml) - Staphylococcus epidermidis 37 (MIC=2µg/ml) - Staphylococcus epidermidis 42 (MIC=2µg/ml) - Staphylococcus epidermidis 44 (MIC=4µg/ml) - Staphylococcus epidermidis 60 (MIC=2µg/ml) - Staphylococcus epidermidis 93 (MIC=2µg/ml) - Staphylococcus epidermidis 156 (MIC=0.0625µg/ml) - Staphylococcus epidermidis RP62A (MIC=2-4µg/ml) - Staphylococcus saprophyticus (MIC=0.5-1µg/ml) - Staphylococcus hominis (MIC=1µg/ml) - Staphylococcus warneri (MIC=1µg/ml) - Enterococcus faecalis (MIC=1µg/ml) - VRE 1 (MIC=1µg/ml) - VRE 2 (MIC=1µg/ml) - VRE 3 (MIC=1µg/ml) - VRE 4 (MIC=1-2µg/ml) - VRE 5 (MIC=0.5-1µg/ml) - VRE 6 (MIC=0.5µg/ml) - MRSA s37 (EMRSA 15) (MIC=1-2µg/ml) - MRSA s41 (EMRSA 15) (MIC=1-2µg/ml) - MRSA s71 (EMRSA 15) (MIC=2µg/ml) - Staphylococcus aureus 1195 (MIC=2µg/ml)
Physicochemical properties: Stable at pH range from 2-10.
UniProt Entry: H9BG66
PDB EntryUnknown
PubMed=22155816;DOI=10.1128/AAC.05397-11
Sandiford S., Upton M.
"Identification, characterisation and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis displaying potent activity against staphylococci ", Antimicrob. Agents Chemother. AAC.05397-11 (2011).
Gene id | Name | Description | Location |
BACGene947 | epidermicin locus structural protein ecdA | 1..156 |
........10 ........20 ........30 ........40 ........50 ........60 | | | | | | MAAFMKLIQF LATKGQKYVS LAWKHKGTIL KWINAGQSFE WIYKQIKKLW A |
Formula | C0
H0
N0
O0
S0 |
Absent amino acids | CDPR |
Common amino acids | K |
Mass (Da) | 6045.7 |
Net charge | +9 |
Isoelectric point | 10.95 |
Basic residues | 10 |
Acidic residues | 1 |
Hydrophobic residues | 24 |
Polar residues | 10 |
Aliphatic residues | 11 |
Tiny residues | 11 |
Boman Index | -12.56 |
Hydropathy Index | -0.02 |
Aliphatic Index | 93.92 |
Instability Index | 19.52 (stable) |
Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 24980 M-1 cm-1 |
Absorbance 280nm | 499.6 |
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