Bacteriocin: Epidermicin NI01

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Bacteriocin: Epidermicin NI01

Accession: BAC210

Classification
Class: Unclassified
Genetics
Gene: edcA
Producer and target organisms

Producer Organism: Staphylococcus epidermidis 224 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesStaphylococcus

Target organismsStaphylococcus epidermidis 1 (MIC=1µg/ml) - Staphylococcus epidermidis 2 (MIC=4µg/ml) - Staphylococcus epidermidis 37 (MIC=2µg/ml) - Staphylococcus epidermidis 42 (MIC=2µg/ml) - Staphylococcus epidermidis 44 (MIC=4µg/ml) - Staphylococcus epidermidis 60 (MIC=2µg/ml) - Staphylococcus epidermidis 93 (MIC=2µg/ml) - Staphylococcus epidermidis 156 (MIC=0.0625µg/ml) - Staphylococcus epidermidis RP62A (MIC=2-4µg/ml) - Staphylococcus saprophyticus (MIC=0.5-1µg/ml) - Staphylococcus hominis (MIC=1µg/ml) - Staphylococcus warneri (MIC=1µg/ml) - Enterococcus faecalis (MIC=1µg/ml) - VRE 1 (MIC=1µg/ml) - VRE 2 (MIC=1µg/ml) - VRE 3 (MIC=1µg/ml) - VRE 4 (MIC=1-2µg/ml) - VRE 5 (MIC=0.5-1µg/ml) - VRE 6 (MIC=0.5µg/ml) - MRSA s37 (EMRSA 15) (MIC=1-2µg/ml) - MRSA s41 (EMRSA 15) (MIC=1-2µg/ml) - MRSA s71 (EMRSA 15) (MIC=2µg/ml) - Staphylococcus aureus 1195 (MIC=2µg/ml)

Description
Activity: Epidermicin does not cause hemolysis or cell toxicity at 100x MIC.
Physicochemical properties: Stable at pH range from 2-10.
Uniprot and PDB links

UniProt Entry: H9BG66

PDB EntryUnknown

PROTEIN SEQUENCE, FUNCTION AND BIOPHYSICOCHEMICAL PROPERTIES
PubMed=22155816;DOI=10.1128/AAC.05397-11
Sandiford S., Upton M.
"Identification, characterisation and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis displaying potent activity against staphylococci ", Antimicrob. Agents Chemother. AAC.05397-11 (2011).
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Gene structure
genome of Epidermicin NI01

Gene idNameDescriptionLocation
BACGene947epidermicin locus structural protein ecdA1..156
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 
          |          |          |          |          |          | 
 MAAFMKLIQF LATKGQKYVS LAWKHKGTIL KWINAGQSFE WIYKQIKKLW A

Wheel representation
wheel representation of Epidermicin NI01
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids CDPR
Common amino acids K
Mass (Da) 6045.7
Net charge +9
Isoelectric point 10.95
Basic residues 10
Acidic residues 1
Hydrophobic residues 24
Polar residues 10
Aliphatic residues 11
Tiny residues 11
Boman Index -12.56
Hydropathy Index -0.02
Aliphatic Index 93.92
Instability Index 19.52 (stable)
Half Life Mammalian : 30 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 24980 M-1 cm-1
Absorbance 280nm 499.6

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