Bacteriocin: Leucocyclicin Q

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Bacteriocin: Leucocyclicin Q

Accession: BAC209

Classification

Class: ~~Unclassified~~

Genetics

Gene: lcyQ

Producer and target organisms

Producer Organism: Leuconostoc mesenteroides TK41401 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLeuconostoc

Target organismsLactococcus lactis ssp. lactis JCM 7638 (MIC=0.038µM) - Lactococcus lactis ssp. lactis ATCC 19435 (MIC=0.038µM) - Lactococcus sp. QU 12 (MIC=1.203µM) - Lactobacillus sakei ssp. sakei JCM 1157 (MIC=0.038µM) - Weissella cibaria JCM 12495 (MIC=2.405µM) - Weissella paramesenteroides JCM 9890 (MIC=0.075µM) - Pediococcus pentosaceus JCM 5885 (MIC=2.405µM) - Pediococcus dextrinicus JCM 5887 (MIC=0.038µM) - Enterococcus faecium JCM 5804 (MIC=0.038µM) - Enterococcus faecalis JCM 5803 (MIC=0.15µM) - Streptococcus salivarius JCM 5707 (MIC=2.405µM) - Streptococcus bovis JCM 5802 (MIC=0.601µM) - Streptococcus mutans JCM 5705 (MIC=19.25µM) - Bacillus coagulans JCM 2257 (MIC=0.075µM) - Bacillus subtilis ssp. subtilis JCM 1465 (MIC=0.601µM) - Bacillus cereus JCM 2152 (MIC=2.405µM) - Kocuria rhizophila NBRC 12708 (MIC=9.623µM) - Listeria innocua ATCC 33090 (MIC=0.601µM) - Leuconostoc mesenteroides ssp. mes. JCM 6124 (MIC=0.3µM) - Escherichia coli JM109 (MIC=38.49µM) - Escherichia coli NBRC 3301 (MIC=38.49µM) -

NOTE: No activity against Leu. mesenteroides TK41401 & Staphylococcus aureus ssp. aureus ATCC 12600 (>38.49 µM).

Uniprot and PDB links

UniProt Entry: G5ELQ0

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

PROTEIN SEQUENCE, FUNCTION AND BIOPHYSICOCHEMICAL PROPERTIES
PubMed=21948835;DOI=10.1128/AEM.06348-11
Masuda Y., Ono H., Kitagawa H., Ito H., Mu F., Sawa N., Zendo T., Sonomoto K.
"Identification and Characterization of Leucocyclicin Q, a Novel Cyclic Bacteriocin Produced by Leuconostoc mesenteroides TK41401.", Appl. Environ. Microbiol. (2011).

Gene structure

Gene id	Name	Description	Location
BACGene942	lcyR	putative trancriptional regulator	complement(181..936)
BACGene943	lcyQ	leucocyclicin Q	1181..1372
BACGene944	lcyB	membrane protein	1481..2131
BACGene945	lcyC	immunity protein	2138..2872
BACGene946	lcyD	immunity protein membrane protein	2856..3383

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60 ........70
| | | | | | |
MFLVNQLGIS KSLANTILGA IAVGNLASWL LALVPGPGWA TKAALATAET IVKHEGKAAA IAW

precursor

Wheel representation

Composition

Hydrophobicity

Composition

Formula	C₀ H₀ N₀ O₀ S₀
Absent amino acids	CDRY
Common amino acids	A
Mass (Da)	6412.23
Net charge	+3
Isoelectric point	10.33
Basic residues	5
Acidic residues	2
Hydrophobic residues	36
Polar residues	16
Aliphatic residues	18
Tiny residues	23
Boman Index	41.92
Hydropathy Index	0.795
Aliphatic Index	127.3
Instability Index	6.4 (stable)
Half Life	Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	16500 M^-1 cm^-1
Absorbance 280nm	266.13

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