Bacteriocin: Bacillocin 1580

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Bacteriocin: Bacillocin 1580

Accession: BAC206

Classification
Class: Class IIa
Genetics
Gene: Unidentified
Producer and target organisms
Description
BIOPHYSICOCHEMICAL PROPERTIES:
- Stable from pH 3.0-9.0, inactivated at pH 10.0;
- Thermostable, activity is retained after incubation at 100 degrees Celsius for 15 minutes;
- Antimicrobial activity is lost upon treatment with beta-chymotrypsin, proteinase K and papain, but not when treated with lysozyme or lipase.
Uniprot and PDB links

UniProt Entry: P86394

PDB EntryUnknown

PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY, STRAIN=NRRL B-30509.
PubMed=15690798;
Svetoch E.A., Stern N.J., Eruslanov B.V., Kovalev Y.N., Volodina L.I., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Pokhilenko V.D., Borzenkov V.N., Levchuk V.P., Svetoch O.E., Kudriavtseva T.Y.
"Isolation of Bacillus circulans and Paenibacillus polymyxa strains inhibitory to Campylobacter jejuni and characterization of associated bacteriocins.", J. Food Prot. 68:11-17(2005).
FUNCTION, STRAIN=NRRL B-30509.
PubMed=16977842;
Cole K., Farnell M.B., Donoghue A.M., Stern N.J., Svetoch E.A., Eruslanov B.N., Volodina L.I., Kovalev Y.N., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Levchuk V.P., Pokhilenko V.D., Borzenkov V.N., Svetoch O.E., Kudryavtseva T.Y., Reyes-Herrera I., Blore P.J., Solis de los Santos F., Donoghue D.J.
"Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults.", Poult Sci. 85(9):1570-5 (2006).
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Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 VNYGNGVSCS KTKCSVNWGI ITHQAFRVTS GVASG

Wheel representation
wheel representation of Bacillocin 1580
Protein sequence annotations
Features of Bacillocin 1580


FeaturePosition(s)LengthDescription
CHAIN1↔3535
Bacteriocin SRCAM 1580.
Feature identifier = PRO_0000390700.
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids DELMP
Common amino acids GSV
Mass (Da) 3
Net charge +4
Isoelectric point 9.5
Basic residues 4
Acidic residues 0
Hydrophobic residues 11
Polar residues 19
Aliphatic residues 7
Tiny residues 12
Boman Index -34.76
Hydropathy Index 0.046
Aliphatic Index 69.43
Instability Index -0.89 (stable)
Half Life Mammalian : 100 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 7115 M-1 cm-1
Absorbance 280nm 209.26

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