Bacteriocin: Bacillocin 602
Accession: BAC204
Classification
Class: Class IIa
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Paenibacillus polymyxa (Bacillus polymyxa) [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacillalesPaenibacillaceaePaenibacillus
Target organismsCamplyobacter jejuni
Description
BIOPHYSICOCHEMICAL PROPERTIES:
- Stable from pH 3.0-9.0, inactivated at pH 10.0;
- Thermostable, activity is retained after incubation at 100 degrees Celsius for 15 minutes;
- Antimicrobial activity is lost upon treatment with beta-chymotrypsin, proteinase K and papain, but not when treated with lysozyme or lipase.
- Stable from pH 3.0-9.0, inactivated at pH 10.0;
- Thermostable, activity is retained after incubation at 100 degrees Celsius for 15 minutes;
- Antimicrobial activity is lost upon treatment with beta-chymotrypsin, proteinase K and papain, but not when treated with lysozyme or lipase.
Uniprot and PDB links
UniProt Entry: P86393
PDB EntryUnknown
PROTEIN SEQUENCE, FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY, STRAIN=NRRL B-30509.
PubMed=15690798;
Svetoch E.A., Stern N.J., Eruslanov B.V., Kovalev Y.N., Volodina L.I., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Pokhilenko V.D., Borzenkov V.N., Levchuk V.P., Svetoch O.E., Kudriavtseva T.Y.
"Isolation of Bacillus circulans and Paenibacillus polymyxa strains inhibitory to Campylobacter jejuni and characterization of associated bacteriocins.", J. Food Prot. 68:11-17(2005).
PubMed=15690798;
Svetoch E.A., Stern N.J., Eruslanov B.V., Kovalev Y.N., Volodina L.I., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Pokhilenko V.D., Borzenkov V.N., Levchuk V.P., Svetoch O.E., Kudriavtseva T.Y.
"Isolation of Bacillus circulans and Paenibacillus polymyxa strains inhibitory to Campylobacter jejuni and characterization of associated bacteriocins.", J. Food Prot. 68:11-17(2005).
FUNCTION, STRAIN=NRRL B-30509.
PubMed=16977842;
Cole K., Farnell M.B., Donoghue A.M., Stern N.J., Svetoch E.A., Eruslanov B.N., Volodina L.I., Kovalev Y.N., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Levchuk V.P., Pokhilenko V.D., Borzenkov V.N., Svetoch O.E., Kudryavtseva T.Y., Reyes-Herrera I., Blore P.J., Solis de los Santos F., Donoghue D.J.
"Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults.", Poult Sci. 85(9):1570-5 (2006).
PubMed=16977842;
Cole K., Farnell M.B., Donoghue A.M., Stern N.J., Svetoch E.A., Eruslanov B.N., Volodina L.I., Kovalev Y.N., Perelygin V.V., Mitsevich E.V., Mitsevich I.P., Levchuk V.P., Pokhilenko V.D., Borzenkov V.N., Svetoch O.E., Kudryavtseva T.Y., Reyes-Herrera I., Blore P.J., Solis de los Santos F., Donoghue D.J.
"Bacteriocins reduce Campylobacter colonization and alter gut morphology in turkey poults.", Poult Sci. 85(9):1570-5 (2006).
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Protein sequence
| ........10 ........20 ........30 ........40 | | | | ATYYGNGLYC NKQKHYTWVD WNKASREIGK IIVNGWVQH |
Wheel representation
Protein sequence annotations
| Feature | Position(s) | Length | Description |
| CHAIN | 1↔39 | 39 | Bacteriocin SRCAM 602. Feature identifier = PRO_0000390699. |
Composition
Hydrophobicity
Composition
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | FMP |
| Common amino acids | KGYN |
| Mass (Da) | 4 |
| Net charge | +5 |
| Isoelectric point | 9.59 |
| Basic residues | 7 |
| Acidic residues | 2 |
| Hydrophobic residues | 12 |
| Polar residues | 16 |
| Aliphatic residues | 7 |
| Tiny residues | 7 |
| Boman Index | -61.26 |
| Hydropathy Index | -0.774 |
| Aliphatic Index | 67.44 |
| Instability Index | 25.76 (stable) |
| Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 22460 M-1 cm-1 |
| Absorbance 280nm | 591.05 |
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