Bacteriocin: Thurincin H

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Bacteriocin: Thurincin H

Accession: BAC201

Classification
Class: Lantibiotic
Genetics
Gene: tucA1; Synonyms=thnA1, thnA2, thnA3, tucA2, tucA3
Producer and target organisms

Producer Organism: Bacillus thuringiensis SF361 [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Target organismsActive [− (no activity) to ++++ (highest activity)] against : Bacillus subtilis ATCC 6633 (++) - Bacillus subtilis ATCC 6537 (+) - Bacillus subtilis CU1065 5(WT) (+++) - Bacillus subtilis LRB90 (+) - Bacillus subtilis LRB91 (+) - Bacillus cereus F4552 (+++++) - Bacillus cereus F4810 (+++++) - Bacillus cereus Northl - ) - Bacillus cereus Northview P2E018 (+++++) - Geobacillus stearothermophilus ATCC 12980 (+++++) - Bacillus thuringiensis EG10368 (+++++) - Bacillus megaterium LRB89 (+++++) - Listeria monocytogenes F2 586 1053 (++++) - Listeria monocytogenes 2289 (++++) - Listeria innocua ATCC 2283 (+++++) - Listeria ivanovii ATCC 19119 (+++++) - Micrococcus luteus (+) - Staphylococcus aureus ATCC 9144 (+) - Staphylococcus aureus ATCC 8095 (+) - Carnobacterium piscicola CU216 (+++++) -

NOT active against: Bacillus cereus ATCC 11778 - Paenibacillus kobensis M - Staphylococcus aureus ATCC 25923 - Lactobacillus acidophilus L-39 - Lactobacillus plantarum B246 - Lactobacillus plantarum EH22G - Lactobacillus helveticus L-31 - Lactobacillus delbrueckii 4797 - Lactobacillus buchneri ATCC 4005 - Lactobacillus fermentum ATCC14931 - Lactobacillus casei 30SC - Lactobacillus brevis B155 - Leuconostoc mesenteroides C-33 - Leuconostoc mesenteroides 548D - Enterococcus faecalis 8043 - Pediococcus cerevisiae E66 - Escherichia coli BF2 - Escherichia coli O157:H7 ATCC 43889 - Salmonella Typhimurium ATCC 14028 - Salmonella Typhimurium Montevideo - Salmonella Enteritidis

Description
STRUCTURE:
Thurincin H is post-translationally modified, with four S-Cα thioether crosslinks (Ref 3).
Uniprot and PDB links

UniProt Entry: B5U2V4

PDB Entry2LBZ resolved by NMR

NUCLEOTIDE SEQUENCE.
PubMed=19083012;DOI=10.1007/s00425-008-0870-6
Lee K.D., Gray E.J., Mabood F., Jung W.J., Charles T., Clark S.R., Ly A., Souleimanov A., Zhou X., Smith D.L.
"The class IId bacteriocin thuricin-17 increases plant growth.", Planta 229:747-755(2009).
NUCLEOTIDE SEQUENCE, STRAIN=SF361.
PubMed=19732155;DOI=10.1111/j.1574-6968.2009.01749.x
Lee H., Churey J.J., Worobo R.W.
"Biosynthesis and transcriptional analysis of thurincin H, a tandem repeated bacteriocin genetic locus, produced by Bacillus thuringiensis SF361.", FEMS Microbiol. Lett. 299:205-213(2009).
STRUCTURE, STRAIN=SF361.
PubMed=21786372;DOI=10.1002/anie.201102527
Sit C.S., van Belkum M.J., McKay R.T., Worobo R.W., Vederas J.C.
"The 3 D Solution Structure of Thurincin H, a Bacteriocin with Four Sulfur to α-Carbon Crosslinks.", Angew Chem Int Ed Engl. (2011).
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End Note
Reference Manager
BibTeX
Gene structure
genome of Thurincin H

Gene idNameDescriptionLocation
BACGene903thnPThnP putative leader peptide-processing serine proteasecomplement(1..1398)
BACGene904thnEThnE ABC transporter; putative permease proteincomplement(1619..2266)
BACGene905thnDThnD ABC transporter; putative ATP-binding proteincomplement(2256..3122)
BACGene906thnRThnR GntR family transcriptional regulator; putative response regulatorcomplement(3119..3502)
BACGene907thnA1thurincin H precursor bacteriocin precursor; thurincin H13822..3944
BACGene908thnA2thurincin H precursor bacteriocin precursor; thurincin H24051..4173
BACGene909thnA3thurincin H precursor bacteriocin precursor; thurincin H34279..4401
BACGene910thnBThnB Fe-S oxidoreductase; radical SAM domain protein; putative bacteriocin processingprotein4566..5945
BACGene911thnTThnT ABC transporter; putative ABC-family secretion protein6110..7819
BACGene912thnIThnI putative immunity protein7854..8141
thnPthnEthnDthnRthnA1thnA2thnA3thnBthnTthnI
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 DWTCWSCLVC AACSVELLNL VTAATGASTA S

Wheel representation
wheel representation of Thurincin H
3D Structure
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids FHIKMPQRY
Common amino acids A
Mass (Da) 3139.51
Net charge -2
Isoelectric point 3.55
Basic residues 0
Acidic residues 2
Hydrophobic residues 15
Polar residues 14
Aliphatic residues 7
Tiny residues 11
Boman Index 7.33
Hydropathy Index 0.965
Aliphatic Index 97.74
Instability Index 35.15 (stable)
Half Life Mammalian : 1.1 hour
Yeast : 3 min
E. coli : >10 hour
Extinction Coefficient 11250 M-1 cm-1
Absorbance 280nm 375

Users comments for Thurincin H

  • Riadh Hammami (Canada) Says:

    Producer strain is now specified: Bacillus thuringiensis SF361 thanks for your comment


  • ELIZABETH MARTINEZ (Mexico) Says:

    DOES ANYONE KNOWS WHICH STRAINS OF BT PRODUCE THURINCIN H ? THANKS


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