Bacteriocin: Hominicin
Accession: BAC183
Classification
Class: lantibiotic
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Staphylococcus hominis MBBL 2–9 [Gram-positive]
Taxonomy: Bacteria
FirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus
Target organismsStaphylococcus aureus ATCC 25923 (MIC=0.06µg/ml) - Staphylococcus aureus (MRSA) ATCC 11435 (MIC=0.96µg/ml) - Staphylococcus aureus (vancomycin-intermediate VISA) CCARM 3501 (MIC=3.82µg/ml)
Description
Structure: Hominicin is post-translationally modified at its respective 1st, 2nd, 5th, 8th, 15th, and 21st residues. The structural property of hominicin present that this peptide is a Class I variant without thioether bridge. It contains modified amino acids: 2-amino-2-butenoic acid (dhb), N2, N2-dimethyl-1,2-propanediamine (dmp) and N1, N1-dimethyl-isoleucine (DmIle).
Note: Hominicin exhibited heat stability up to 121 °C for 15 min and activity under both acidic and basic conditions (from pH 2.0 to 10.0). [Ref1]
Note: Hominicin exhibited heat stability up to 121 °C for 15 min and activity under both acidic and basic conditions (from pH 2.0 to 10.0). [Ref1]
Uniprot and PDB links
UniProt Entry: No entry found
PDB EntryUnknown
PROTEIN SEQUENCE, FUNCTION AND MASS SPECTROMETRY
PubMed=20654578;DOI=10.1016/j.bbrc.2010.07.024
Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG.
"Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2–9", Biochem Biophys Res Commun. 399(2):133-8(2010).
PubMed=20654578;DOI=10.1016/j.bbrc.2010.07.024
Kim PI, Sohng JK, Sung C, Joo HS, Kim EM, Yamaguchi T, Park D, Kim BG.
"Characterization and structure identification of an antimicrobial peptide, hominicin, produced by Staphylococcus hominis MBBL 2–9", Biochem Biophys Res Commun. 399(2):133-8(2010).
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Protein sequence
| ........10 ........20 ........30 | | | XTPATPFTPA ITEITAAVIA X |
Wheel representation
Composition
Hydrophobicity
Composition
| Formula | C0
H0
N0
O0
S0 |
| Absent amino acids | CDGHKLMNQRSWY |
| Common amino acids | TA |
| Mass (Da) | 1 |
| Net charge | -1 |
| Isoelectric point | 3.85 |
| Basic residues | 0 |
| Acidic residues | 1 |
| Hydrophobic residues | 10 |
| Polar residues | 5 |
| Aliphatic residues | 4 |
| Tiny residues | 5 |
| Boman Index | 11.17 |
| Hydropathy Index | 0.843 |
| Aliphatic Index | 93.33 |
| Instability Index | 54.43 (unstable) |
| Half Life |
Mammalian : 0 Yeast : 0 E. coli : 0 |
| Extinction Coefficient | 0 M-1 cm-1 |
| Absorbance 280nm | 0 |
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