Bacteriocin: Avicin A

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Bacteriocin: Avicin A

Accession: BAC180

Gene: avcA
Producer and target organisms

Producer Organism: Enterococcus avium [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsActive against Carnobacterium divergens NCDO 2763 (MIC=1.25 nM) - Carnobacterium divergens NCDO 2306 (MIC=2.51 nM) - Carnobacterium piscicola NCDO 2762 (MIC=0.31 nM) - Carnobacterium piscicola NCDO 2764 (MIC=0.31 nM) - Enterococcus avium GM62 2(MIC=0.63 nM) - Enterococcus avium UA62 2(MIC=5.02 nM) - Enterococcus avium UM83 (MIC=0.31 nM) - Enterococcus faecalis EF BRIDGE (B) (MIC=10.04 nM) - Enterococcus maldoratus XM83 (MIC=5.02 nM) - Lactobacillus rhamnosus 205 5(MIC=<0.31 nM) - Lactobacillus sakei NCDO 2714 (MIC=1.25 nM) - Leuconostoc lactis NCDO 533 (MIC=5.02 nM) - Leuconostoc mesenteroides NCDO 529 (MIC=2.51 nM) - Listeria innocua BL86/26 B B(MIC=<0.31 nM) - Listeria monocytogenes 223 serotype 1 (MIC=<0.31 nM) - Listeria monocytogenes 400 serotype 4 (MIC=<0.31 nM) - Pediococcus acidilactici NCDO 1851 (MIC=40.16 nM) - Pediococcus pentosaceus NCDO 814 (MIC=20.08 nM) -

Note: The MICs varied within ±30%. -

Note: Inactive against Enterococcus faecalis LMGT 2708RA - Lactobacillus sakei 5 - Lactococcus lactis IL 1403 - Lactococcus lactis CM4 - Leuconostoc gelidum Ta 11a - Pediococcus acidilactici PacI - Lactobacillus plantarum LMG 2003

Uniprot and PDB links

UniProt Entry: D2DXK5

PDB EntryUnknown

Birri DJ, Brede DA, Forberg T, Holo H, Nes IF.
"Molecular and genetic characterization of a novel bacteriocin locus in Enterococcus avium isolates from infants. ", Journal of Applied Microbiology 76(2):483-92.
End Note
Reference Manager
Gene structure
genome of Avicin A

Gene idNameDescriptionLocation
BACGene834celFputative maltose-6-phosphate glucosidase321..1646
BACGene835avcAavicin A precursor class IIa (pediocin-like) bacteriocin1928..2113
BACGene836avcIputative immunity protein2153..2446
BACGene837avcBavicin B bacteriocin-like protein; divergicin A-like bacteriocin2812..3015
BACGene838avcTputative ABC transporter3376..5553
BACGene839avcKputative histidine protein kinase5621..6949
BACGene840avcRputative response regulator6958..7692
BACGene841avcFputative inducing peptide7877..8014
BACGene842avcDputative transport accessory protein8025..8540
Protein sequence
 ........10 ........20 ........30 ........40 ........50 
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Wheel representation
wheel representation of Avicin A

Formula C0 H0 N0 O0 S0
Absent amino acids EFHMPQR
Common amino acids G
Mass (Da) 4
Net charge +3
Isoelectric point 9.33
Basic residues 4
Acidic residues 1
Hydrophobic residues 14
Polar residues 24
Aliphatic residues 6
Tiny residues 19
Boman Index -33.18
Hydropathy Index -0.188
Aliphatic Index 63.72
Instability Index 8.24 (stable)
Half Life Mammalian : 7.2 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 14105 M-1 cm-1
Absorbance 280nm 335.83

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