Bacteriocin: Leucocin N

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Bacteriocin: Leucocin N

Accession: BAC179

Classification
Class: Class IId
Genetics
Gene: lccN
Producer and target organisms

Producer Organism: Leuconostoc pseudomesenteroides QU 15 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesLeuconostoc

Target organismsBacillus circulans JCM 2504T (5.20 µmol/l) - Listeria innocua ATCC 33090 (1.30 µmol/l) - Listeria monocytogenes ATCC BAA-679 (1.30 µmol/l) - Enterococcus faecalis JCM 5803 (5.20 µmol/l) - Lactobacillus plantarum ATCC 14917 (2.60 µmol/l) - Lactobacillus sakei ssp. sakei JCM 1157 (1.30 µmol/l) - Leuconostoc mesenteroides ssp. mesenteroides JCM 6124 (2.60 µmol/l) -

Note: not active against Bacillus coagulans JCM 2257 - Bacillus subtilis JCM 1465T - Kocuria rhizophila NBRC 12708 - Lactococcus lactis ssp. lactis ATCC 19435 - Pediococcus pentosaceus JCM 5885

Description
Leuc. pseudomesenteroides QU 15 (isolated from Nukadoko) produce at least three bacteriocins, leucocin A, and two novel bacteriocins termed leucocin Q and leucocin N.
Uniprot and PDB links

UniProt Entry: D7UPI9

PDB EntryUnknown

PROTEIN SEQUENCE, STRAIN=QU 15
PubMed=20070442;DOI=10.1111/j.1365-2672.2009.04653.x
Sawa N, Okamura K, Zendo T, Himeno K, Nakayama J, Sonomoto K.
"Identification and characterization of novel multiple bacteriocins produced by Leuconostoc pseudomesenteroides QU 15", Journal of Applied Microbiology (2010).
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End Note
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Gene structure
genome of Leucocin N

Gene idNameDescriptionLocation
BACGene832LccQleucocin Q34..195
BACGene833LccNleucocin N223..396
LccQLccN
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 KGLGKLIGID WLLGQAKDAV KQYKKDYKRW H

Wheel representation
wheel representation of Leucocin N
Composition
Hydrophobicity

Composition
Formula C0 H0 N0 O0 S0
Absent amino acids CEFMNPST
Common amino acids K
Mass (Da) 3
Net charge +6
Isoelectric point 10.55
Basic residues 9
Acidic residues 3
Hydrophobic residues 11
Polar residues 6
Aliphatic residues 7
Tiny residues 6
Boman Index -50.35
Hydropathy Index -0.855
Aliphatic Index 91.29
Instability Index 43.61 (unstable)
Half Life Mammalian : 1.3 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 13980 M-1 cm-1
Absorbance 280nm 466

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