Bacteriocin: Microcin-24

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Bacteriocin: Microcin-24

Accession: BAC176

Classification

Class: ~~Unclassified~~

Genetics

Gene: mtfS

Producer and target organisms

Producer Organism: Escherichia coli [Gram-negative]

Taxonomy: BacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Target organisms~~Unavailable data~~

Description

Channel-forming bacteriocin

Uniprot and PDB links

UniProt Entry: Q46971

PDB Entry~~Unknown~~

[Ref. 1]

NUCLEOTIDE SEQUENCE [GENOMIC DNA].STRAIN=2424;
O'Brien G.J., Mahanty H.K.
"Complete nucleotide sequence of microcin 24 genetic region andanalysis of a new ABC transporter.", Submitted (JAN-1996) to the EMBL/GenBank/DDBJ database

Gene structure

Gene id	Name	Description	Location
BACGene815	mdbA	microcin DNA binding protein	94..609
BACGene816	mtfI	microcin 24 immunity protein immunity to microcin 24	854..1135
BACGene817	mtfS	microcin 24 precursor toxin mcc24	1126..1398
BACGene818	mtfA	MtfA microcin 24 transport	1873..3117
BACGene819	mtfB	MtfB mirocin 24 transport (ABC transporter)	3107..5230

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80
| | | | | | | |
AGDPLADPNS QIVRQIMSNA AWGPPLVPER FRGMAVGAAG GVTQTVLQGA AAHMPVNVPI PKVPMGPSWN GSKG

Wheel representation

Protein sequence annotations

Feature	Position(s)	Length	Description
CHAIN	1↔74	74	Microcin-24. Feature identifier = PRO_0000005678.

Composition

Hydrophobicity

Composition

Formula	C₃₃₂ H₅₂₉ N₉₇ O₉₅ S₄
Absent amino acids	CY
Common amino acids	AGP
Mass (Da)	7546.94
Net charge	+3
Isoelectric point	10.76
Basic residues	6
Acidic residues	3
Hydrophobic residues	27
Polar residues	20
Aliphatic residues	14
Tiny residues	24
Boman Index	-45.85
Hydropathy Index	-0.03
Aliphatic Index	76.49
Instability Index	36.99 (stable)
Half Life	Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	11000 M^-1 cm^-1
Absorbance 280nm	150.68

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