Bacteriocin: Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)

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Bacteriocin: Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)

Accession: BAC171

Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms

Producer Organism: Bacillus cereus (strain ATCC 14579 / DSM 31) [Gram-positive]

Taxonomy: BacteriaFirmicutesBacillalesBacillaceaeBacillusBacillus cereus group

Target organismsBacillus subtilis PCI219 - Bacillus anthracis - Staphylococcus aureus FDA209P - Staphylococcus aureus Smith - Staphylococcus aureus 80257 - Streptococcus pyogenes C-203 - Streptococcus pneumoniae type D -

note: not active against Gram-negative bacteria

Uniprot and PDB links

UniProt Entry: Q812G9

PDB EntryUnknown

POST-TRANSLATIONAL MODIFICATIONS.
PubMed=19196969;DOI=10.1073/pnas.0900008106
Brown L.C.W., Acker M.G., Clardy J., Walsh C.T., Fischbach M.A.;"
"Thirteen posttranslational modifications convert a 14-residue peptideinto the antibiotic thiocillin.";", Proc. Natl. Acad. Sci. U.S.A. 106:2549-2553(2009)

PubMed=819410;
Shoji, J., Hinoo, H., Wakisaka, Y., Koizumi, K., and Mayama, M.
"Isolation of three new antibiotics, thiocillins I, II and III, related to micrococcin P. Studies on antibiotics from the genus Bacillus.", J. Antibiot. (Tokyo) 29,366-374(1976)
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Protein sequence
 ........10 ........20 
          |          | 
 SCTTCVCTCS CCTT

Wheel representation
wheel representation of Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)
Protein sequence annotations
Features of Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)

TVTTT
FeaturePosition(s)LengthDescription
PEPTIDE1↔1414
Thiocillin.
Feature identifier = PRO_0000363166.
Modified residue4(Z)-2,3-didehydrobutyrine.
Modified residue63-hydroxyvaline; partial.
Modified residue8O-methylthreonine; partial.
Modified residue13(Z)-2,3-didehydrobutyrine.
Modified residue141-amino-2-propanone; alternate.
Modified residue14Decarboxylated threonine; alternate.
Cross-link1↔1010Pyridine-2,5-dicarboxylic acid (Ser-Ser)(with C-47).
Cross-link1↔99Pyridine-2,5-dicarboxylic acid (Ser-Cys)(with S-48).
Cross-link1↔22Thiazole-4-carboxylic acid (Ser-Cys).
Cross-link4↔52Thiazole-4-carboxylic acid (Thr-Cys).
Cross-link6↔72Thiazole-4-carboxylic acid (Val-Cys).
Cross-link8↔92Thiazole-4-carboxylic acid (Thr-Cys).
Cross-link10↔112Thiazole-4-carboxylic acid (Ser-Cys).
Cross-link11↔122Thiazole-4-carboxylic acid (Cys-Cys).
Composition
Hydrophobicity

Composition
Formula C49 H86 N14 O22 S6
Absent amino acids ADEFGHIKLMNPQRWY
Common amino acids C
Mass (Da) 1433.89
Net charge 0
Isoelectric point 5.61
Basic residues 0
Acidic residues 0
Hydrophobic residues 1
Polar residues 13
Aliphatic residues 1
Tiny residues 2
Boman Index -7.93
Hydropathy Index 1.01
Aliphatic Index 20.71
Instability Index 120.33 (unstable)
Half Life Mammalian : 1.9 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 0 M-1 cm-1
Absorbance 280nm 28.85

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