Bacteriocin: Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)
Bacteriocin: Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)
Accession: BAC171
Classification
Class: Unclassified
Genetics
Gene: Unidentified
Producer and target organisms
Producer Organism: Bacillus cereus (strain ATCC 14579 / DSM 31) [Gram-positive]
Taxonomy: BacteriaFirmicutes
Bacillales
Bacillaceae
Bacillus
Bacillus cereus group
Target organismsBacillus subtilis PCI219 - Bacillus anthracis - Staphylococcus aureus FDA209P - Staphylococcus aureus Smith - Staphylococcus aureus 80257 - Streptococcus pyogenes C-203 - Streptococcus pneumoniae type D -
note: not active against Gram-negative bacteria
Uniprot and PDB links
UniProt Entry: Q812G9
PDB EntryUnknown
POST-TRANSLATIONAL MODIFICATIONS.
PubMed=19196969;DOI=10.1073/pnas.0900008106
Brown L.C.W., Acker M.G., Clardy J., Walsh C.T., Fischbach M.A.;"
"Thirteen posttranslational modifications convert a 14-residue peptideinto the antibiotic thiocillin.";", Proc. Natl. Acad. Sci. U.S.A. 106:2549-2553(2009)
PubMed=19196969;DOI=10.1073/pnas.0900008106
Brown L.C.W., Acker M.G., Clardy J., Walsh C.T., Fischbach M.A.;"
"Thirteen posttranslational modifications convert a 14-residue peptideinto the antibiotic thiocillin.";", Proc. Natl. Acad. Sci. U.S.A. 106:2549-2553(2009)
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
MEDLINE=22608415;PubMed=12721630;DOI=10.1038/nature01582
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
"Genome sequence of Bacillus cereus and comparative analysis withBacillus anthracis", Nature 423:87-91(2003)
MEDLINE=22608415;PubMed=12721630;DOI=10.1038/nature01582
Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V., Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M., Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G., Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.C.
"Genome sequence of Bacillus cereus and comparative analysis withBacillus anthracis", Nature 423:87-91(2003)
Loading...
Protein sequence
........10 ........20 | | SCTTCVCTCS CCTT |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
PEPTIDE | 1↔14 | 14 | Thiocillin. Feature identifier = PRO_0000363166. |
Modified residue | 4 | (Z)-2,3-didehydrobutyrine. | |
Modified residue | 6 | 3-hydroxyvaline; partial. | |
Modified residue | 8 | O-methylthreonine; partial. | |
Modified residue | 13 | (Z)-2,3-didehydrobutyrine. | |
Modified residue | 14 | 1-amino-2-propanone; alternate. | |
Modified residue | 14 | Decarboxylated threonine; alternate. | |
Cross-link | 1↔10 | 10 | Pyridine-2,5-dicarboxylic acid (Ser-Ser)(with C-47). |
Cross-link | 1↔9 | 9 | Pyridine-2,5-dicarboxylic acid (Ser-Cys)(with S-48). |
Cross-link | 1↔2 | 2 | Thiazole-4-carboxylic acid (Ser-Cys). |
Cross-link | 4↔5 | 2 | Thiazole-4-carboxylic acid (Thr-Cys). |
Cross-link | 6↔7 | 2 | Thiazole-4-carboxylic acid (Val-Cys). |
Cross-link | 8↔9 | 2 | Thiazole-4-carboxylic acid (Thr-Cys). |
Cross-link | 10↔11 | 2 | Thiazole-4-carboxylic acid (Ser-Cys). |
Cross-link | 11↔12 | 2 | Thiazole-4-carboxylic acid (Cys-Cys). |
Composition
Hydrophobicity
Composition
Formula | C49
H86
N14
O22
S6 |
Absent amino acids | ADEFGHIKLMNPQRWY |
Common amino acids | C |
Mass (Da) | 1433.89 |
Net charge | 0 |
Isoelectric point | 5.61 |
Basic residues | 0 |
Acidic residues | 0 |
Hydrophobic residues | 1 |
Polar residues | 13 |
Aliphatic residues | 1 |
Tiny residues | 2 |
Boman Index | -7.93 |
Hydropathy Index | 1.01 |
Aliphatic Index | 20.71 |
Instability Index | 120.33 (unstable) |
Half Life |
Mammalian : 1.9 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 0 M-1 cm-1 |
Absorbance 280nm | 28.85 |
Users comments for Thiocillin (Micrococcin P1) (Micrococcin P2) (Thiocillin I) (Thiocillin II) (Thiocillin III) (Thiocillin IV) (Antibiotic YM-266183) (Antibiotic YM-266184)
No comments found