Bacteriocin: Lacticin Q
Accession: BAC169
Classification
Class: Unclassified
Genetics
Gene: lnqQ
Producer and target organisms
Producer Organism: Lactococcus lactis QU 5 [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesStreptococcaceaeLactococcus
Target organismsBrochothrix campestris ATCC 43754 (MIC=2µM) - Carnobacterium divergens LV13 (MIC=2µM) - Carnobacterium maltaromaticum UAL26 (MIC=1µM) - Carnobacterium maltaromaticum UAL26 (pMG36c-cclBITCDA) (MIC=16µM) - Enterococcus faecalis ATCC 7080 (MIC=32µM) - Enterococcus faecium BFE900 (MIC=4µM) - Lactobacillus acidophilus M46 (MIC=0.5µM) - Lactobacillus sakei UAL1218 (MIC=0.5µM) - Lactococcus lactis ATCC 19257 (MIC=0.06µM) - Staphylococcus aureus ATCC 29213 (MIC=32µM) - Staphylococcus aureus ATCC 6538 (MIC=8µM)
Uniprot and PDB links
UniProt Entry: A4UVR2
PDB Entry2N8P resolved by NMR
NUCLEOTIDE SEQUENCE
PubMed=17351096;
Fujita K., Ichimasa S., Zendo T., Koga S., Yoneyama F., Nakayama J., Sonomoto K.
"Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria", Appl. Environ. Microbiol. 73:2871-2877(2007)
PubMed=17351096;
Fujita K., Ichimasa S., Zendo T., Koga S., Yoneyama F., Nakayama J., Sonomoto K.
"Structural analysis and characterization of lacticin Q, a novel bacteriocin belonging to a new family of unmodified bacteriocins of gram-positive bacteria", Appl. Environ. Microbiol. 73:2871-2877(2007)
STRUCTURE
PubMed=26771761;DOI=10.1021/acs.biochem.5b01306
Acedo J.Z., van Belkum M.J., Lohans C.T., Towle K.M., Miskolzie M., Vederas J.C.
"Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.", Biochemistry 2016, ():.
PubMed=26771761;DOI=10.1021/acs.biochem.5b01306
Acedo J.Z., van Belkum M.J., Lohans C.T., Towle K.M., Miskolzie M., Vederas J.C.
"Nuclear Magnetic Resonance Solution Structures of Lacticin Q and Aureocin A53 Reveal a Structural Motif Conserved among Leaderless Bacteriocins with Broad-Spectrum Activity.", Biochemistry 2016, ():.
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Gene structure
| Gene id | Name | Description | Location |
| BACGene782 | collagen-binding protein orf1 | 993..2873 | |
| BACGene783 | putative transcriptional regulator orf2 | complement(3827..4402) | |
| BACGene784 | lnqQ | lacticin Q | 4840..5001 |
| BACGene785 | lnqQ | membrane permease protein orf3 | 5078..5317 |
| BACGene786 | lnqQ | membrane-franked domain protein orf4 | 5295..5774 |
| BACGene787 | lnqQ | membrane-franked domain protein orf5 | 5764..7062 |
| BACGene788 | lnqQ | ABC-2 type transporter orf6 | 7062..7739 |
| BACGene789 | lnqQ | ABC transporter, ATP-binding protein orf7 | 7806..8600 |
| BACGene790 | lnqQ | putative transcriptional regulator orf8 | complement(10192..10872) |
| BACGene791 | lnqQ | replication protein orf9 | 12793..14124 |
| BACGene792 | lnqQ | DNA integrase/recombinase orf10 | 14523..15650 |
| BACGene793 | lnqQ | ATP/GTP binding protein orf11 | complement(15711..16553) |
Protein sequence
| ........10 ........20 ........30 ........40 ........50 ........60 | | | | | | AGFLKVVQLL AKYGSKAVQW AWANKGKILD WLNAGQAIDW VVSKIKQILG IK |
Wheel representation
3D Structure
Composition
Hydrophobicity
Composition
| Formula | C279
H445
N71
O67
S1 |
| Absent amino acids | CEHPRT |
| Common amino acids | KA |
| Mass (Da) | 5917.05 |
| Net charge | +6 |
| Isoelectric point | 10.84 |
| Basic residues | 8 |
| Acidic residues | 2 |
| Hydrophobic residues | 28 |
| Polar residues | 10 |
| Aliphatic residues | 16 |
| Tiny residues | 14 |
| Boman Index | 2.12 |
| Hydropathy Index | 0.3 |
| Aliphatic Index | 121.51 |
| Instability Index | 7.38 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 23490 M-1 cm-1 |
| Absorbance 280nm | 451.73 |
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