Bacteriocin: Bacteriocin T8

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Bacteriocin: Bacteriocin T8

Accession: BAC167

Classification
Class: class IIa
Genetics
Gene: bacA
Producer and target organisms

Producer Organism: Enterococcus faecium T8 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsEnterococcus faecalis MDK1 - Enterococcus faecalis MDK2 - Enterococcus faecalis MDK3 - Enterococcus faecalis MDK4 - Enterococcus faecalis MDK5 - Lactobacillus sakei LMG 13558 - Enterococcus faecalis LMG 13566 - Enterococcus faecalis BFE 1071 - Propionibacterium sp. LMG 13574 - note: not active against Lactobacillus acidophilus LMG 13550 - Lactobacillus bulgaricus LMG 13551 - Lactobacillus casei LMG 13552 - Lactobacillus casei LHS - Lactobacillus curvatus LMG 13553 - Lactobacillus curvatus DF 38 - Lactobacillus fermentum LMG 13554 - Lactobacillus helveticus LMG 13555 - Lactobacillus plantarum LMG 13556 - Lactobacillus reuteri LMG 13557 - Lactobacillus salivarius 241 - Pediococcus pentosaceus LMG 13560 - Pediococcus pentosaceus LMG 13561 - Leuconostoc cremoris LMG 13562 - Leuconostoc cremoris LMG 13563 - Streptococcus thermophilus LMG 13564 - Streptococcus thermophilus LMG 13565 - Staphylococcus carnosus LMG 13567 - Listeria innocua LMG LMG 13568 - Bacillus cereus LMG 13569 - Clostridium sporogenes LMG 13570 - Clostridium tyrobutyricum LMG 13571

NUCLEOTIDE SEQUENCE
PubMed=16820469;
De Kwaadsteniet M., Fraser T., Van Reenen C.A., Dicks L.M.
"Bacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.", Appl. Environ. Microbiol. 72:4761-4766(2006)
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End Note
Reference Manager
BibTeX
Gene structure
genome of Bacteriocin T8

Gene idNameDescriptionLocation
BACGene773bacAbacteriocin precursor122..346
BACGene774bacBhypothetical protein366..653
BACGene775mobCmobilization protein1103..1483
BACGene776mobAmobilization protein1465..2379
BACGene777mobAhypothetical protein orf52171..2617
BACGene778mobAhypothetical protein orf62624..3313
BACGene779repAreplication protein4157..5101
BACGene780repBreplication protein5122..5655
BACGene781repBhypothetical protein orf95670..5840
bacAbacBmobCmobAmobAmobArepArepBrepB
Protein sequence
 ........10 ........20 ........30 ........40 
          |          |          |          | 
 TYYGNGLYCN KEKCWVDWNQ AKGEIGKIIV NGWVNH

Wheel representation
wheel representation of Bacteriocin T8
Composition
Hydrophobicity

Composition
Formula C191 H279 N51 O53 S2
Absent amino acids FMPRS
Common amino acids GN
Mass (Da) 4220.36
Net charge +2
Isoelectric point 8.21
Basic residues 5
Acidic residues 3
Hydrophobic residues 11
Polar residues 16
Aliphatic residues 7
Tiny residues 6
Boman Index -43.07
Hydropathy Index -0.64
Aliphatic Index 70.28
Instability Index 2.93 (stable)
Half Life Mammalian : 7.2 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 20970 M-1 cm-1
Absorbance 280nm 602.71

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