Bacteriocin: Bacteriocin T8
Accession: BAC167
Producer Organism: Enterococcus faecium T8 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Enterococcaceae
Enterococcus
Target organismsEnterococcus faecalis MDK1 - Enterococcus faecalis MDK2 - Enterococcus faecalis MDK3 - Enterococcus faecalis MDK4 - Enterococcus faecalis MDK5 - Lactobacillus sakei LMG 13558 - Enterococcus faecalis LMG 13566 - Enterococcus faecalis BFE 1071 - Propionibacterium sp. LMG 13574 - note: not active against Lactobacillus acidophilus LMG 13550 - Lactobacillus bulgaricus LMG 13551 - Lactobacillus casei LMG 13552 - Lactobacillus casei LHS - Lactobacillus curvatus LMG 13553 - Lactobacillus curvatus DF 38 - Lactobacillus fermentum LMG 13554 - Lactobacillus helveticus LMG 13555 - Lactobacillus plantarum LMG 13556 - Lactobacillus reuteri LMG 13557 - Lactobacillus salivarius 241 - Pediococcus pentosaceus LMG 13560 - Pediococcus pentosaceus LMG 13561 - Leuconostoc cremoris LMG 13562 - Leuconostoc cremoris LMG 13563 - Streptococcus thermophilus LMG 13564 - Streptococcus thermophilus LMG 13565 - Staphylococcus carnosus LMG 13567 - Listeria innocua LMG LMG 13568 - Bacillus cereus LMG 13569 - Clostridium sporogenes LMG 13570 - Clostridium tyrobutyricum LMG 13571
UniProt Entry: Q27HG2
PDB EntryUnknown
PubMed=16820469;
De Kwaadsteniet M., Fraser T., Van Reenen C.A., Dicks L.M.
"Bacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.", Appl. Environ. Microbiol. 72:4761-4766(2006)
Gene id | Name | Description | Location |
BACGene773 | bacA | bacteriocin precursor | 122..346 |
BACGene774 | bacB | hypothetical protein | 366..653 |
BACGene775 | mobC | mobilization protein | 1103..1483 |
BACGene776 | mobA | mobilization protein | 1465..2379 |
BACGene777 | mobA | hypothetical protein orf5 | 2171..2617 |
BACGene778 | mobA | hypothetical protein orf6 | 2624..3313 |
BACGene779 | repA | replication protein | 4157..5101 |
BACGene780 | repB | replication protein | 5122..5655 |
BACGene781 | repB | hypothetical protein orf9 | 5670..5840 |
........10 ........20 ........30 ........40 | | | | TYYGNGLYCN KEKCWVDWNQ AKGEIGKIIV NGWVNH |
Formula | C191
H279
N51
O53
S2 |
Absent amino acids | FMPRS |
Common amino acids | GN |
Mass (Da) | 4220.36 |
Net charge | +2 |
Isoelectric point | 8.21 |
Basic residues | 5 |
Acidic residues | 3 |
Hydrophobic residues | 11 |
Polar residues | 16 |
Aliphatic residues | 7 |
Tiny residues | 6 |
Boman Index | -43.07 |
Hydropathy Index | -0.64 |
Aliphatic Index | 70.28 |
Instability Index | 2.93 (stable) |
Half Life |
Mammalian : 7.2 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 20970 M-1 cm-1 |
Absorbance 280nm | 602.71 |
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