Bacteriocin: Bacteriocin T8

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Bacteriocin: Bacteriocin T8

Accession: BAC167

Classification

Class: class IIa

Genetics

Gene: bacA

Producer and target organisms

Producer Organism: Enterococcus faecium T8 [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesEnterococcaceaeEnterococcus

Target organismsEnterococcus faecalis MDK1 - Enterococcus faecalis MDK2 - Enterococcus faecalis MDK3 - Enterococcus faecalis MDK4 - Enterococcus faecalis MDK5 - Lactobacillus sakei LMG 13558 - Enterococcus faecalis LMG 13566 - Enterococcus faecalis BFE 1071 - Propionibacterium sp. LMG 13574 - note: not active against Lactobacillus acidophilus LMG 13550 - Lactobacillus bulgaricus LMG 13551 - Lactobacillus casei LMG 13552 - Lactobacillus casei LHS - Lactobacillus curvatus LMG 13553 - Lactobacillus curvatus DF 38 - Lactobacillus fermentum LMG 13554 - Lactobacillus helveticus LMG 13555 - Lactobacillus plantarum LMG 13556 - Lactobacillus reuteri LMG 13557 - Lactobacillus salivarius 241 - Pediococcus pentosaceus LMG 13560 - Pediococcus pentosaceus LMG 13561 - Leuconostoc cremoris LMG 13562 - Leuconostoc cremoris LMG 13563 - Streptococcus thermophilus LMG 13564 - Streptococcus thermophilus LMG 13565 - Staphylococcus carnosus LMG 13567 - Listeria innocua LMG LMG 13568 - Bacillus cereus LMG 13569 - Clostridium sporogenes LMG 13570 - Clostridium tyrobutyricum LMG 13571

Uniprot and PDB links

UniProt Entry: Q27HG2

PDB Entry~~Unknown~~

[Ref. 1] | View abstract | Export citation

NUCLEOTIDE SEQUENCE
PubMed=16820469;
De Kwaadsteniet M., Fraser T., Van Reenen C.A., Dicks L.M.
"Bacteriocin T8, a novel class IIa sec-dependent bacteriocin produced by Enterococcus faecium T8, isolated from vaginal secretions of children infected with human immunodeficiency virus.", Appl. Environ. Microbiol. 72:4761-4766(2006)

Gene structure

Gene id	Name	Description	Location
BACGene773	bacA	bacteriocin precursor	122..346
BACGene774	bacB	hypothetical protein	366..653
BACGene775	mobC	mobilization protein	1103..1483
BACGene776	mobA	mobilization protein	1465..2379
BACGene777	mobA	hypothetical protein orf5	2171..2617
BACGene778	mobA	hypothetical protein orf6	2624..3313
BACGene779	repA	replication protein	4157..5101
BACGene780	repB	replication protein	5122..5655
BACGene781	repB	hypothetical protein orf9	5670..5840

Protein sequence

........10 ........20 ........30 ........40
| | | |
TYYGNGLYCN KEKCWVDWNQ AKGEIGKIIV NGWVNH

Wheel representation

Composition

Hydrophobicity

Composition

Formula	C₁₉₁ H₂₇₉ N₅₁ O₅₃ S₂
Absent amino acids	FMPRS
Common amino acids	GN
Mass (Da)	4220.36
Net charge	+2
Isoelectric point	8.21
Basic residues	5
Acidic residues	3
Hydrophobic residues	11
Polar residues	16
Aliphatic residues	7
Tiny residues	6
Boman Index	-43.07
Hydropathy Index	-0.64
Aliphatic Index	70.28
Instability Index	2.93 (stable)
Half Life	Mammalian : 7.2 hour Yeast : >20 hour E. coli : >10 hour
Extinction Coefficient	20970 M^-1 cm^-1
Absorbance 280nm	602.71

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