Bacteriocin: Uberolysin
Accession: BAC162
Classification
Class: Unclassified
Genetics
Gene: ublA
Producer and target organisms
Producer Organism: Streptococcus uberis strain 42 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsEnterococcus faecalis - Enterococcus hirae - Lactococcus lactis - Listeria innocua - Listeria ivanovii - Micrococcus luteus - Staphylococcus aureus - Streptococcus agalactiae - Streptococcus anginosus - Streptococcus dysgalactiae - Streptococcus equisimilis - Streptococcus pyogenes - Streptococcus salivarius
Uniprot and PDB links
UniProt Entry: A5H1G9
PDB EntryUnknown
NUCLEOTIDE SEQUENCE
PubMed=17464077;DOI=10.1099/mic.0.2006/005967-0
Wirawan R.E., Swanson K.M., Kleffmann T., Jack R.W., Tagg J.R.
"Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis.", Microbiology, 153(5):1619-30(2007).
PubMed=17464077;DOI=10.1099/mic.0.2006/005967-0
Wirawan R.E., Swanson K.M., Kleffmann T., Jack R.W., Tagg J.R.
"Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis.", Microbiology, 153(5):1619-30(2007).
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Gene structure
Gene id | Name | Description | Location |
BACGene750 | PurH-like protein ORF3 | 170..1330 | |
BACGene751 | possible orphan response regulator ORF1; ComE-like; may be involved in regulation of ublA | complement(1383..2138) | |
BACGene752 | ublA | UblA circular bacteriocin uberolysin | 2438..2668 |
BACGene753 | ublB | UblB putative maturation factor; putative protein involved in uberolysin maturation | 2758..4365 |
BACGene754 | ublC | UblC integral membrane protein; possible accessory factor in uberolysin maturation | 4346..4891 |
BACGene755 | ublD | UblD ABC-transporter; possible exporter of uberolysin | 4876..5532 |
BACGene756 | ublE | UblE ORF2; possible immunity protein | 5529..5795 |
Protein sequence
........10 ........20 ........30 ........40 ........50 ........60 ........70 ........80 | | | | | | | | LAGYTGIASG TAKKVVDAID KGAAAFVIIS IISTVISAGA LGAVSASADF IILTVKNYIS RNLKAQAVIW |
Wheel representation
Protein sequence annotations
Feature | Position(s) | Length | Description |
PEPTIDE | 1↔70 | 70 | Bacteriocin uberolysin. Feature identifier = PRO_0000326413. |
Cross-link | 1↔70 | 70 | Cyclopeptide (Leu-Trp). |
Composition
Hydrophobicity
Composition
Formula | C324
H534
N82
O93
|
Absent amino acids | CEHMP |
Common amino acids | A |
Mass (Da) | 7085.54 |
Net charge | +3 |
Isoelectric point | 10.17 |
Basic residues | 6 |
Acidic residues | 3 |
Hydrophobic residues | 39 |
Polar residues | 21 |
Aliphatic residues | 22 |
Tiny residues | 27 |
Boman Index | 19.34 |
Hydropathy Index | 0.94 |
Aliphatic Index | 132.57 |
Instability Index | -2.28 (stable) |
Half Life |
Mammalian : 5.5 hour Yeast : 3 min E. coli : 2 min |
Extinction Coefficient | 8480 M-1 cm-1 |
Absorbance 280nm | 122.9 |
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