Bacteriocin: Durancin TW-49M

Accession: BAC159

Classification

Class: ~~Unclassified~~

Genetics

Gene: durM

Producer and target organisms

Producer Organism: Enterococcus durans QU 49 [Gram-positive]

Target organismsEnterococcus faecalis JCM 5803 - Enterococcus faecium TUA 1344L - Enterococcus hirae ATCC 10541 - Lactobacillus alimentarius JCM 1095 - Lactobacillus kimchii JCM 10707 - Lactobacillus plantarum ATCC 14917 - Lactobacillus sakei ssp. sakei JCM 1157 - Lactococcus lactis ssp. lactis ATCC 19435 - Geobacillus stearothermophilus JCM 2501 - Bacillus subtilis JCM 1465 - Bacillus coagulans JCM 2257 - Bacillus circulans JCM 2504 -

note: not active against Gram-negative bacteria: Enterococcus faecium JCM 5804 - Lactobacillus brevis JCM 1059 - Lactobacillus casei ssp. casei JCM 1134 - Lactobacillus collinoides JCM 1123 - Lactobacillus coryniformis ssp. coryniformis JCM 1164 - Bacillus cereus JCM 2152 - Listeria innocua ATCC 33090 - Micrococcus luteus NBRC 12708 - Escherichia coli JM109

Related Entries

Uniprot and PDB links

UniProt Entry: B3IUC6

PDB Entry~~Unknown~~

Gene structure

Gene id	Name	Description	Location
BACGene730		hypothetical protein ORF1	1..936
BACGene731	cda	CDA cytosine deaminase cytosine deaminase homologue	complement(1219..2418)
BACGene732	durI	DurI immunity protein of durancin TW-49M	2555..2827
BACGene733	durM	precursor of durancin TW-49M DurM; non-pediocin-like class II bacteriocin	complement(3019..3237)
BACGene734	durF	DurF precursor of durancin TW-49M inducing peptide	3468..3593
BACGene735	durK	DurK histidine protein kinase homologue	3636..4931
BACGene736	durR	DurR response regulator homologue	4942..5688
BACGene737	durT	DurT ABC transporter homologue	6427..8577
BACGene738	durD	DurD accessory protein homologue	8595..9959
BACGene739	ims	IMS ImpB/MucB/SamB family protein ImpB/MucB/SamB family protein homologue	10217..11545
BACGene740	orf11	hypothetic protein ORF11; hypothetic protein	11523..11885
BACGene741	ofr12	hypothetic protein ORF12	11976..12155

Protein sequence

........10 ........20 ........30 ........40 ........50 ........60
| | | | | |
ENDHRMPYEL NRPNNLSKGG AKCAAGILGA GLGAVGGGPG GFISAGISAV LGCM

Wheel representation

Composition

Hydrophobicity

Composition

Formula	C₂₂₃ H₃₆₂ N₆₈ O₆₉ S₄
Absent amino acids	QTW
Common amino acids	G
Mass (Da)	5246.92
Net charge	+2
Isoelectric point	8.23
Basic residues	5
Acidic residues	3
Hydrophobic residues	18
Polar residues	23
Aliphatic residues	10
Tiny residues	23
Boman Index	-22.27
Hydropathy Index	0.13
Aliphatic Index	81.48
Instability Index	27.86 (stable)
Half Life	Mammalian : 1hour Yeast : 30 min E. coli : >10 hour
Extinction Coefficient	1490 M^-1 cm^-1
Absorbance 280nm	30.47

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