Bacteriocin: Columbicin A
Accession: BAC157
Classification
Class: Lantibiotic
Genetics
Gene: colA
Producer and target organisms
Producer Organism: Enterococcus columbae [Gram-positive]
Taxonomy: Bacteria
FirmicutesLactobacillalesEnterococcaceaeEnterococcus
Target organismsUnavailable data
Uniprot and PDB links
UniProt Entry: A0FL76
PDB EntryUnknown
[Ref. 1]
Martin M., Brede D.A., Herranz C., Nes I.F., Cintas L.M., Hernandez P.E.
""Amino acid and nucleotide sequence of columbicin A, a novel lantibiotic variant produced by Enterococcus columbae PLCH2, isolated from wood pigeons (Columba palumbus)."",
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Gene structure
| Gene id | Name | Description | Location |
| BACGene728 | colA | columbicin A class I lantibiotic variant; antimicrobial peptide | 146..322 |
| BACGene729 | colA | hypothetical protein orfB | 404..536 |
Protein sequence
| ........10 ........20 ........30 ........40 ........50 ........60 | | | | | | MMNATENQIF VETVSDQELE MLIGGAGRGW IKTLTKDCPN VISSICAGTI ITACKNCA |
Wheel representation
Composition
Hydrophobicity
Composition
| Formula | C263
H435
N71
O86
S7 |
| Absent amino acids | HY |
| Common amino acids | IT |
| Mass (Da) | 6211.2 |
| Net charge | -2 |
| Isoelectric point | 4.39 |
| Basic residues | 4 |
| Acidic residues | 6 |
| Hydrophobic residues | 20 |
| Polar residues | 22 |
| Aliphatic residues | 13 |
| Tiny residues | 13 |
| Boman Index | -46.96 |
| Hydropathy Index | 0.24 |
| Aliphatic Index | 90.86 |
| Instability Index | 26.79 (stable) |
| Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
| Extinction Coefficient | 5500 M-1 cm-1 |
| Absorbance 280nm | 100.88 |
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