Bacteriocin: Bovicin HJ50
Accession: BAC156
Producer Organism: Streptococcus bovis HJ50 [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsBacillus megaterium AS1.941 - Bacillus subtilis AS1.1087 - Lactobacillus curvatus LTH1174 - Leuconostoc mesenteroides AS1.2 - Leuconostoc dextranicum 181 - Micrococcus flavus NCIB8166 - note: not active against Bacillus cereus - Bacillus coagulans AS1.949 - Escherichia coli - Enterococcus faecalis - Lactobacillus acidophilus - Lactobacillus brevis - Lactobacillus buchneri AS1.40 - Lactobacillus plantarum - Listeria monocytogenes - Pseudomonas aeruginosa 10105 - Shigella flexneri 51285 - Staphylococcus aureus 26071
UniProt Entry: Q83ZN8
PDB Entry2M8V resolved by NMR
Gene id | Name | Description | Location |
BACGene713 | DNA methylase | 1..2728 | |
BACGene714 | hypothetical protein orf1 | 2798..3097 | |
BACGene715 | hypothetical protein orf2 | 3112..3402 | |
BACGene716 | bovA | BovA | 3541..3717 |
BACGene717 | bovM | BovM putative lantibiotic modification enzyme | 3798..6311 |
BACGene718 | bovT | BovT putative lantibiotic transporter | 6325..8367 |
BACGene719 | bovF | BovF putative component of the bovicin HJ50 transporter complex responsible forimmunity to bovicin HJ50 | 8342..9250 |
BACGene720 | bovE | BovE putative component of the bovicin HJ50 transporter complex responsible forimmunity to bovicin HJ50 | 9234..9956 |
BACGene721 | bovG | BovG putative component of the bovicin HJ50 transporter complex responsible forimmunity to bovicin HJ50 | 9969..10679 |
BACGene722 | bovK | BovK histidine kinase for bovicin operon expression | 10669..12180 |
BACGene723 | bovR | BovR response regulator for bovicin operon expression | 12158..12754 |
BACGene724 | bovI | BovI putative lipopeptide for immunity to bovicin HJ50 | 12823..12981 |
BACGene725 | sdb1 | Sdb1 thiol-disulfide isomerase and thioredoxin | 12992..13477 |
BACGene726 | sdb1 | hypothetical protein orf3 | 13691..14341 |
BACGene727 | sdb1 | hypothetical protein orf4 | 14381..14995 |
........10 ........20 ........30 ........40 | | | | GADRGWIKTL TKDCPNVISS ICAGTIITAC KNCA |
Feature | Position(s) | Length | Description |
PEPTIDE | 1↔34 | 34 | Lantibiotic Bovicin HJ50.
Feature identifier = |
Modified residue | 9 | d-alpha-aminobutyric acid. | |
Modified residue | 11 | d-alpha-aminobutyric acid. | |
Cross-link | 22↔30 | 9 | disulfide bond (Cys-Cys). |
TURN | 11↔12 | 2 | |
TURN | 18↔21 | 4 |
Formula | C147
H248
N42
O46
S4 |
Absent amino acids | EFHMQY |
Common amino acids | I |
Mass (Da) | 3428.3 |
Net charge | +2 |
Isoelectric point | 8.34 |
Basic residues | 4 |
Acidic residues | 2 |
Hydrophobic residues | 12 |
Polar residues | 15 |
Aliphatic residues | 7 |
Tiny residues | 9 |
Boman Index | -28.3 |
Hydropathy Index | 0.276 |
Aliphatic Index | 89.12 |
Instability Index | 22.04 (stable) |
Half Life |
Mammalian : 30 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 5750 M-1 cm-1 |
Absorbance 280nm | 174.24 |
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