Bacteriocin: Thermophilin 1277
Accession: BAC155
Producer Organism: Streptococcus thermophilus [Gram-positive]
Taxonomy: BacteriaFirmicutes
Lactobacillales
Streptococcaceae
Streptococcus
Target organismsStreptomyces thermophilus SBT10137 - Streptomyces thermophilus SBT10814 - Streptomyces thermophilus ATCC19258 - Streptomyces thermophilus SBT10813 - Streptomyces thermophilus SBT10838 - Streptomyces thermophilus SBT10914 - Lactobacillus acidophilus JCM1132 - Lactobacillus delbrueckii subsp. bulgaricus SBT0164 - Lactobacillus helveticus SBT10511 - Lactobacillus helveticus SBT2171 - Lactobacillus helveticus SBT1270 - Lactococcus lactis subsp. lactis ATCC11454 - Microbacterium lacticum SBT3513 - Microbacterium lacticum BT3514 - Enterococcus fecalis BT3515 - Clostridium butylicum SBT3516 - Clostridium sprogenes IFH 493 - Clostridium tyrobutylicum SBT3517 - Bacillus cereus IFO13494 -
Note: not active against Lactobacillus gasseri SBT2055 - Lactobacillus gasseri JCM1131 - Staphylococcus aureus ATCC25923 - Listeria innocua IFH178 - Listeria innocua IFH180 - Listeria monocytogenes IFH181 - Listeria monocytogenes IFH182 - Listeria monocytogenes IFH179
UniProt Entry: A7M695
PDB EntryUnknown
PubMed=17381740;DOI=10.1111/j.1365-2672.2006.03159.x
Kabuki T., Uenishi H., Watanabe M., Seto Y., Nakajima H.
"Characterization of a bacteriocin, Thermophilin 1277, produced by Streptococcus thermophilus SBT1277.", J. Appl. Microbiol. 102(4):971-980(2007)
PubMed=19191960;
Kabuki T., Uenishi H., Seto Y., Yoshioka T., Nakajima H.
"A unique lantibiotic, thermophilin 1277, containing a disulfide bridge and two thioether bridges.", J. Appl. Microbiol. 106(3):853-862(2009)
Gene id | Name | Description | Location |
BACGene693 | hypothetical protein | 1..1050 | |
BACGene694 | hypothetical protein | 1120..1419 | |
BACGene695 | hypothetical protein | 1432..1722 | |
BACGene696 | tepA | thermophilin 1277 | 1861..2037 |
BACGene697 | tepM | hypothetical bacteriocin modified enzyme | 2118..4631 |
BACGene698 | tepT | hypothetical bacteriocin transporter | 4645..6687 |
BACGene699 | tepF | hypothetical bacteriocin immunity protein | 6662..7570 |
BACGene700 | tepF | hypothetical protein | 7554..8276 |
BACGene701 | tepF | hypothetical protein | 8283..8999 |
BACGene702 | tepK | hypothetical bacteriocin immunity protein | 8989..10500 |
BACGene703 | tepR | hypothetical bacteriocin immunity protein | 10721..11074 |
BACGene704 | tepR | hypothetical protein | 11143..11301 |
BACGene705 | tepR | hypothetical protein | 11313..11798 |
BACGene706 | tepR | hypothetical protein | 12012..12662 |
BACGene707 | tepR | hypothetical protein | 12702..13790 |
BACGene708 | tepR | hypothetical protein | 13844..14071 |
BACGene709 | tepR | hypothetical protein | 14075..14470 |
BACGene710 | tepR | hypothetical protein | complement(14831..15130) |
BACGene711 | tepR | hypothetical protein | complement(15117..15485) |
BACGene712 | tepR | hypothetical protein | complement(15482..16402) |
........10 ........20 ........30 ........40 | | | | ADRGWIKTLT KDCPNVISSI CAGTIITACK NCA |
Formula | C147
H248
N42
O46
S4 |
Absent amino acids | EFHMQY |
Common amino acids | I |
Mass (Da) | 3486.66 |
Net charge | +2 |
Isoelectric point | 8.34 |
Basic residues | 4 |
Acidic residues | 2 |
Hydrophobic residues | 12 |
Polar residues | 14 |
Aliphatic residues | 7 |
Tiny residues | 8 |
Boman Index | -29.24 |
Hydropathy Index | 0.3 |
Aliphatic Index | 91.82 |
Instability Index | 24.98 (stable) |
Half Life |
Mammalian : 4.4 hour Yeast : >20 hour E. coli : >10 hour |
Extinction Coefficient | 5500 M-1 cm-1 |
Absorbance 280nm | 179.69 |
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