Bacteriocin: duramycin-C

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Bacteriocin: duramycin-C

Accession: BAC152

Classification
Class: lanthionin
Genetics
Gene: Unidentified
Producer and target organisms
Uniprot and PDB links

UniProt Entry: P36503

PDB EntryUnknown

STRUCTURE by NMR of duramycin-C
PubMed=8375380;
Zimmermann N., Freund S., Fredenhagen A., Jung G.
"Solution structures of the lantibiotics duramycin B and C.", Eur. J. Biochem. 216(2):419-28(1993)
structure of duramycin-C
PubMed=2125590;
Fredenhagen A., Fendrich G., Märki F., Märki W., Gruner J., Raschdorf F., Peter HH.
"Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin.", J. Antibiot. (Tokyo) 43(11):1403-1412(1990
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Protein sequence
 ........10 ........20 
          |          | 
 CANSCSYGPL TWSCDGNTK

Wheel representation
wheel representation of duramycin-C
Protein sequence annotations
Features of duramycin-C


FeaturePosition(s)LengthDescription
PEPTIDE1↔1919
Lantibiotic duramycin-C.
Feature identifier = PRO_0000043972.
Cross-link1↔1818Beta-methyllanthionine (Cys-Thr).
Cross-link4↔1411Lanthionine (Ser-Cys).
Cross-link5↔117Beta-methyllanthionine (Cys-Thr).
Cross-link6↔1914Lysinoalanine (Ser-Lys).
Composition
Hydrophobicity

Composition
Formula C82 H123 N23 O30 S3
Absent amino acids EFHIMQRV
Common amino acids CS
Mass (Da) 2025.5
Net charge 0
Isoelectric point 6
Basic residues 1
Acidic residues 1
Hydrophobic residues 3
Polar residues 13
Aliphatic residues 1
Tiny residues 6
Boman Index -28.25
Hydropathy Index -0.51
Aliphatic Index 25.79
Instability Index 32.61 (stable)
Half Life Mammalian : 1.2 hour
Yeast : >20 hour
E. coli : >10 hour
Extinction Coefficient 6990 M-1 cm-1
Absorbance 280nm 395.28

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