Bacteriocin: Carnocyclin-A

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Bacteriocin: Carnocyclin-A

Accession: BAC148

Classification
Class: Unclassified
Genetics
Gene: cclA
Producer and target organisms

Producer Organism: Carnobacterium maltaromaticum (Carnobacterium piscicola) [Gram-positive]

Taxonomy: BacteriaFirmicutesLactobacillalesCarnobacteriaceaeCarnobacterium

Target organismsGram-positive: Carnobacterium maltaromaticum UAL26 - Carnobacterium maltaromaticum LV17A - Carnobacterium divergens LV13 - Brochothrix campestris ATCC 43754 - Brochothrix thermosphacta ATCC 11509 - Enterococcus faecalis ATCC 7080 - Enterococcus faecium ATCC 19434 - Enterococcus faecium BFE900 - Lactococcus lactis subsp. lactis ATCC 11454 - Lactococcus lactis subsp. cremoris ATCC 11602 - Lactococcus lactis subsp. lactis DPC3147 - Lactobacillus sakei 706 - Lactobacillus sakei UAL1218 - Leuconostoc mesenteroides Y105 - Pediococcus acidilactici PAC1.0 - Listeria monocytogenes ATCC 15313 - Listeria monocytogenes H7762 - Listeria monocytogenes ATCC 43256 - Listeria monocytogenes HPB 642 - Listeria monocytogenes UAFM 1 - Listeria monocytogenes UAFM 15 - Staphylococcus aureus ATCC 25923 - Staphylococcus aureus ATCC 6538 - Staphylococcus aureus ATCC 29213 -

Note: No activity was observed against the gram-negative strains that were tested.

Description
- Circular bacteriocin

Uniprot and PDB links

UniProt Entry: B2MVM5

PDB Entry2KJF resolved by NMR

NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 5-64, FUNCTION,BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, AND MASSSPECTROMETRY.STRAIN=UAL307;
PubMed=18552180;DOI=10.1128/AEM.00817-08
Martin-Visscher L.A., van Belkum M.J., Garneau-Tsodikova S., Whittal R.M., Zheng J., McMullen L.M., Vederas J.C.;
"Isolation and characterization of carnocyclin a, a novel circularbacteriocin produced by Carnobacterium maltaromaticum UAL307.", Appl. Environ. Microbiol. 74:4756-4763 (2008).
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End Note
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BibTeX
Gene structure
genome of Carnocyclin-A

Gene idNameDescriptionLocation
BACGene665hypothetical protein Orf183..262
BACGene666hypothetical protein Orf2570..821
BACGene667cclBCclB1223..2674
BACGene668cclICclI immunity protein2747..2929
BACGene669cclTCclT ATP-binding protein2958..3584
BACGene670cclCCclC DUF95 family of membrane proteins3562..4140
BACGene671cclDCclD4239..4721
BACGene672cclAcarnocyclin A precursor circular bacteriocin; anti-bacterial peptide4780..4974
BACGene673cclECclE5402..5854
BACGene674cclFCclF putative HlyD-type family of accessory proteins5885..7087
BACGene675cclGCclG ATP-binding protein7084..7767
BACGene676cclHCclH putative ABC transporter permease7764..8960
BACGene677cclHhypothetical protein Orf39197..9319
BACGene678cclHhypothetical protein Orf4complement(10211..10642)
BACGene679trxATrxA TRX family of thioredoxin proteins11267..11698
cclBcclIcclTcclCcclDcclAcclEcclFcclGcclHcclHcclHtrxA
Protein sequence
 ........10 ........20 ........30 ........40 ........50 ........60 ........70 
          |          |          |          |          |          |          | 
 LVAYGIAQGT AEKVVSLINA GLTVGSIISI LGGVTVGLSG VFTAVKAAIA KQGIKKAIQL

Wheel representation
wheel representation of Carnocyclin-A
3D Structure
Protein sequence annotations
Features of Carnocyclin-A


FeaturePosition(s)LengthDescription
PEPTIDE1↔6060
Carnocyclin-A.
Feature identifier = PRO_0000361697.
Cross-link1↔6060Cyclopeptide (Leu-Leu).
CONFLICT28I -> L (in Ref. 1; AA sequence).
TURN2↔54
HELIX8↔1811
TURN19↔213
HELIX24↔318
TURN36↔383
HELIX39↔5113
HELIX54↔596
Composition
Hydrophobicity

Composition
Formula C269 H463 N69 O76
Absent amino acids CDHMPRW
Common amino acids AGIV
Mass (Da) 5862
Net charge +4
Isoelectric point 10.7
Basic residues 5
Acidic residues 1
Hydrophobic residues 32
Polar residues 19
Aliphatic residues 22
Tiny residues 22
Boman Index 47.09
Hydropathy Index 1.06
Aliphatic Index 144.67
Instability Index 5.83 (stable)
Half Life Mammalian : 5.5 hour
Yeast : 3 min
E. coli : 2 min
Extinction Coefficient 1490 M-1 cm-1
Absorbance 280nm 25.25

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